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• W2238493442 abstract "A library of nitric oxide-donor doxorubicins (NO-DOXOs) was synthesized by linking appropriate NO-donor moieties at C-14 position through an ester bridge. Their hydrolytic stability was evaluated. The intracellular accumulation and cytotoxicity of these novel NO-DOXOs were studied in DOXO-sensitive (HT29) and DOXO-resistant (HT29/dx) tumor-cells. Hydrolytically-stable compounds accumulated in HT29 and HT29/dx cells, thanks to the nitration of plasma-membrane efflux transporters. Surprisingly, no close correlation was found between intracellular accumulation and cytotoxicity. Only compounds with high mitochondria retention (due to nitration of mitochondrial efflux transporter) exert high cytotoxicity, through the activation of a mitochondrial-dependent apoptosis." @default.
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• W2238493442 date "2016-03-01" @default.
• W2238493442 modified "2023-10-16" @default.
• W2238493442 title "Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins" @default.
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• W2238493442 doi "https://doi.org/10.1016/j.bmc.2016.01.021" @default.
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