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- W2238493641 abstract "Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca(2+) signalling has been intensely studied, whereas for fish little is known. In sea urchin sperm, a cyclic nucleotide-gated K(+) channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca(2+) influx. Here, we identify in sperm of the freshwater fish Danio rerio a novel CNGK family member featuring non-canonical properties. It is located in the sperm head rather than the flagellum and is controlled by intracellular pH, but not cyclic nucleotides. Alkalization hyperpolarizes sperm and produces Ca(2+) entry. Ca(2+) induces spinning-like swimming, different from swimming of sperm from other species. The spinning mode probably guides sperm into the micropyle, a narrow entrance on the surface of fish eggs. A picture is emerging of sperm channel orthologues that employ different activation mechanisms and serve different functions. The channel inventories probably reflect adaptations to species-specific challenges during fertilization." @default.
- W2238493641 created "2016-06-24" @default.
- W2238493641 creator A5001370177 @default.
- W2238493641 creator A5004950209 @default.
- W2238493641 creator A5005347940 @default.
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- W2238493641 creator A5058670884 @default.
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- W2238493641 creator A5071514219 @default.
- W2238493641 creator A5077560050 @default.
- W2238493641 creator A5090109226 @default.
- W2238493641 date "2015-12-09" @default.
- W2238493641 modified "2023-10-14" @default.
- W2238493641 title "A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm" @default.
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