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- W2238505953 abstract "The HIV envelope (Env) is heavily glycosylated, facilitating the spread and survival of HIV in many ways. Some potent broadly neutralizing antibodies (bnAbs) such as 2G12, PG9, PG16, and PGTs can recognize the conserved glycan residues on Env. The bnAbs, which often emerge after many years of chronic infection, provide insight into the vulnerability of HIV and can therefore guide the design of vaccines. Many carbohydrate-conjugated vaccines have been designed to induce bnAb-like antibodies, but none have yet been successful. The low antigenicity of these vaccines is one possible explanation. New strategies have been applied to obtain high-affinity antigens of glycan-dependent and other bnAbs. However, when used as immunogens in vivo, high-affinity antigens are still insufficient in eliciting bnAb-like antibodies. bnAbs generally possess some unusual features and may therefore be suppressed by the host immune system. In view of this situation, some immunization regimens based on the affinity maturation of antibodies have been tested. Herein we summarize recent studies into the design of carbohydrate-based HIV vaccines and some valuable experiences gained in work with other bnAb-based HIV vaccines." @default.
- W2238505953 created "2016-06-24" @default.
- W2238505953 creator A5012299746 @default.
- W2238505953 creator A5033959946 @default.
- W2238505953 creator A5065426391 @default.
- W2238505953 date "2016-01-13" @default.
- W2238505953 modified "2023-09-26" @default.
- W2238505953 title "Broadly Neutralizing Antibody-Guided Carbohydrate-Based HIV Vaccine Design: Challenges and Opportunities" @default.
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- W2238505953 doi "https://doi.org/10.1002/cmdc.201500498" @default.
- W2238505953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26762799" @default.
- W2238505953 hasPublicationYear "2016" @default.
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