FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238529478> ?p ?o ?g. }

• W2238529478 endingPage "25355" @default.
• W2238529478 startingPage "25343" @default.
• W2238529478 abstract "Lupus nephritis (LN) is a complication of the autoimmune disease systemic lupus erythematosus. Because the complement system plays a critical role in orchestrating inflammatory and immune responses as well as in the clearance of immune complexes, autoreactivity to complement components may have considerable pathological consequences. Autoantibodies against the central complement component C3 have been reported in systemic lupus erythematosus, but their molecular mechanism and functional relevance are not well understood. The objective of this study was to evaluate the frequency and the functional properties of the anti-C3 autoantibodies. Anti-C3 autoantibodies were measured in plasma of 39 LN patients, and identification of their epitopes on the C3 molecule was performed. By using surface plasmon resonance, we analyzed the influence of patient-derived IgG antibodies on the interaction of C3b with Factor B, Factor H, and complement receptor 1. The capacity of these antibodies to dysregulate the C3 convertase on the surface of endothelial cell was measured by flow cytometry. Here we report that the frequency of anti-C3 autoantibodies in LN is ∼30%. They inhibited interactions of the negative complement regulators Factor H and complement receptor 1 with C3b. An enhanced C3 deposition was also observed on human endothelial cells in the presence of C3 autoantibodies. In addition, anti-C3 autoantibody levels correlated with disease activity. In conclusion, the anti-C3 autoantibodies in LN may contribute to the autoimmune pathology by their capacity to overactivate the complement system." @default.
• W2238529478 created "2016-06-24" @default.
• W2238529478 creator A5018405489 @default.
• W2238529478 creator A5025683973 @default.
• W2238529478 creator A5028355665 @default.
• W2238529478 creator A5044274785 @default.
• W2238529478 creator A5048563111 @default.
• W2238529478 creator A5051276814 @default.
• W2238529478 creator A5055407328 @default.
• W2238529478 creator A5075831793 @default.
• W2238529478 creator A5083120113 @default.
• W2238529478 date "2015-10-01" @default.
• W2238529478 modified "2023-10-17" @default.
• W2238529478 title "Functional Characterization of Autoantibodies against Complement Component C3 in Patients with Lupus Nephritis" @default.
• W2238529478 cites W1486365785 @default.
• W2238529478 cites W1499593166 @default.
• W2238529478 cites W1606415249 @default.
• W2238529478 cites W1961930965 @default.
• W2238529478 cites W1965444854 @default.
• W2238529478 cites W1971659350 @default.
• W2238529478 cites W1973996890 @default.
• W2238529478 cites W1974210499 @default.
• W2238529478 cites W1977591188 @default.
• W2238529478 cites W1977810547 @default.
• W2238529478 cites W1979551570 @default.
• W2238529478 cites W1984477907 @default.
• W2238529478 cites W1985524053 @default.
• W2238529478 cites W1986514968 @default.
• W2238529478 cites W1987723450 @default.
• W2238529478 cites W1989256666 @default.
• W2238529478 cites W1995349074 @default.
• W2238529478 cites W2009255343 @default.
• W2238529478 cites W2010694509 @default.
• W2238529478 cites W2026784781 @default.
• W2238529478 cites W2033338567 @default.
• W2238529478 cites W2036694775 @default.
• W2238529478 cites W2038416229 @default.
• W2238529478 cites W2045445076 @default.
• W2238529478 cites W2045534957 @default.
• W2238529478 cites W2053142028 @default.
• W2238529478 cites W2056159723 @default.
• W2238529478 cites W2061272125 @default.
• W2238529478 cites W2074456827 @default.
• W2238529478 cites W2077144266 @default.
• W2238529478 cites W2084955409 @default.
• W2238529478 cites W2088963169 @default.
• W2238529478 cites W2097465080 @default.
• W2238529478 cites W2098315002 @default.
• W2238529478 cites W2101246053 @default.
• W2238529478 cites W2124841845 @default.
• W2238529478 cites W2125750727 @default.
• W2238529478 cites W2132781640 @default.
• W2238529478 cites W2156600899 @default.
• W2238529478 cites W2167003442 @default.
• W2238529478 cites W2172273545 @default.
• W2238529478 cites W255976751 @default.
• W2238529478 cites W4292232933 @default.
• W2238529478 doi "https://doi.org/10.1074/jbc.m115.647008" @default.
• W2238529478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4646184" @default.
• W2238529478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26245903" @default.
• W2238529478 hasPublicationYear "2015" @default.
• W2238529478 type Work @default.
• W2238529478 sameAs 2238529478 @default.
• W2238529478 citedByCount "38" @default.
• W2238529478 countsByYear W22385294782016 @default.
• W2238529478 countsByYear W22385294782017 @default.
• W2238529478 countsByYear W22385294782018 @default.
• W2238529478 countsByYear W22385294782019 @default.
• W2238529478 countsByYear W22385294782020 @default.
• W2238529478 countsByYear W22385294782021 @default.
• W2238529478 countsByYear W22385294782022 @default.
• W2238529478 countsByYear W22385294782023 @default.
• W2238529478 crossrefType "journal-article" @default.
• W2238529478 hasAuthorship W2238529478A5018405489 @default.
• W2238529478 hasAuthorship W2238529478A5025683973 @default.
• W2238529478 hasAuthorship W2238529478A5028355665 @default.
• W2238529478 hasAuthorship W2238529478A5044274785 @default.
• W2238529478 hasAuthorship W2238529478A5048563111 @default.
• W2238529478 hasAuthorship W2238529478A5051276814 @default.
• W2238529478 hasAuthorship W2238529478A5055407328 @default.
• W2238529478 hasAuthorship W2238529478A5075831793 @default.
• W2238529478 hasAuthorship W2238529478A5083120113 @default.
• W2238529478 hasBestOaLocation W22385294781 @default.
• W2238529478 hasConcept C104317684 @default.
• W2238529478 hasConcept C111684460 @default.
• W2238529478 hasConcept C112313634 @default.
• W2238529478 hasConcept C121332964 @default.
• W2238529478 hasConcept C126322002 @default.
• W2238529478 hasConcept C127716648 @default.
• W2238529478 hasConcept C159654299 @default.
• W2238529478 hasConcept C163764329 @default.
• W2238529478 hasConcept C168167062 @default.
• W2238529478 hasConcept C185592680 @default.
• W2238529478 hasConcept C188082640 @default.
• W2238529478 hasConcept C203014093 @default.
• W2238529478 hasConcept C2776912625 @default.
• W2238529478 hasConcept C2777058396 @default.
• W2238529478 hasConcept C2779134260 @default.

• next