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• W2238532470 abstract "SUPRASPINAL AND SPINAL MECHANISMS OF MORPHINE-INDUCED HYPERALGESIA by Caroline A. Arout Adviser: Benjamin Kest, Ph.D. Morphine is the most prominent pharmacological treatment for moderate to severe pain in both acute and chronic paradigms. However, morphine notoriously elicits a paradoxical state of increased pain sensitivity known as hyperalgesia that complicates its use in clinical application. Research over the past three decades has reported that morphine-induced hyperalgesia is doseand sex-dependent, and likely involves the synchronous activity of several neural networks beyond the opioid system. Whereas systemic, supraspinal, and spinal administration of morphine all cause hyperalgesia that is differentially reversible by N-methyl-D-aspartate receptor (NMDAR) antagonists or melanocortin-1 receptor (MC1R) antagonists, it is unknown as to whether or not these non-opioid systems that contribute to this state are located supraspinally or spinally. The current studies were performed with the goal of elucidating the precise location of regulatory action of this sexand dosedependent state of morphine hyperalgesia. In all studies, outbred CD-1 male and female mice were pretreated with the general opioid receptor antagonist, naltrexone (NTX) 24 hours prior to morphine treatment. All mice were subsequently implanted with osmotic pumps, continuously dispensing a low (1.6mg/kg/24h) or" @default.
• W2238532470 created "2016-06-24" @default.
• W2238532470 creator A5022760863 @default.
• W2238532470 date "2014-01-01" @default.
• W2238532470 modified "2023-09-26" @default.
• W2238532470 title "Supraspinal And Spinal Mechanisms Of Morphine-Induced Hyperalgesia" @default.
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