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- W22385945 abstract "When I was a younger researcher working with Frank Schabel in the few years prior to his retirement and death, I would frequently join him in his office to talk science. Often he would be seated at a table with a manuscript he was reviewing spread before him. He would tap some tabulated data or a figure with his finger and then, to be certain of my attention, he would reach over with the same finger and tap me on the arm or knee and say, “We’ve got to teach ‘ern.” Invariably, these data would be offered to support a claim of antitumor activity for a drug in a murine tumor model. Another researcher would be reporting tumor-growth inhibition, but when the numbers were considered critically and analyzed by the standards that Frank insisted on, it would be obvious, even to me, that the tumor burden in the group of treated mice had actually increased during the course of treatment. The nadir of tumor mass suggested a therapeutic response, but the experiment had not been adequately designed to assess it. And so it went. And so it continues." @default.
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- W22385945 date "2002-10-29" @default.
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- W22385945 title "Perspective on the History of Tumor Models" @default.
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- W22385945 doi "https://doi.org/10.1007/978-1-59259-100-8_1" @default.
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