Matches in SemOpenAlex for { <https://semopenalex.org/work/W223860579> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W223860579 endingPage "272" @default.
- W223860579 startingPage "268" @default.
- W223860579 abstract "The in vivo release of four water-soluble drugs, cefadroxil, cephradine, antipyrine and 4-aminoantipyrine, from a stabilizing water-in-oil-in-water (W/O/W) type multiple emulsion was studied using rats. The W/O/W type multiple emulsion used in this study could be stabilized for 30 d after preparation at room temperature and also for 24 h in pH 7.4 isotonic phosphate buffer or in rat plasma at 37 degrees C. The cefadroxil and cephradine concentrations in rat plasma following intravenous administrations of their W/O/W type multiple emulsions containing drugs were considerably prolonged compared with those of respective aqueous solutions. Sustained-releasing properties of cefadroxil and cephradine from W/O/W type multiple emulsions could be explained by the mechanism underlying the long residence time of W/O/W type multiple emulsions and delay-release of drugs from the W/O/W type multiple emulsions circulated with rat blood stream. However, antipyrine and 4-aminoantipyrine decreased rapidly following W/O/W type multiple emulsions and these plasma profiles coincided precisely with those following intravenous administration of the aqueous solutions of drugs. These in vivo releasing data correlated with in vitro drug release observation stated in the previous papers." @default.
- W223860579 created "2016-06-24" @default.
- W223860579 creator A5012380392 @default.
- W223860579 creator A5024264861 @default.
- W223860579 creator A5055231348 @default.
- W223860579 creator A5061036155 @default.
- W223860579 creator A5062612010 @default.
- W223860579 date "1993-01-01" @default.
- W223860579 modified "2023-09-26" @default.
- W223860579 title "Evaluation of Emulsions. Part III. In Vivo Release of Water-Soluble Drugs from Stabilized Water-in-Oil-in-Water (W/O/W) Type Multiple Emulsions Following Intravenous Administrations Using Rats." @default.
- W223860579 doi "https://doi.org/10.1248/bpb.16.268" @default.
- W223860579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8364471" @default.
- W223860579 hasPublicationYear "1993" @default.
- W223860579 type Work @default.
- W223860579 sameAs 223860579 @default.
- W223860579 citedByCount "11" @default.
- W223860579 countsByYear W2238605792023 @default.
- W223860579 crossrefType "journal-article" @default.
- W223860579 hasAuthorship W223860579A5012380392 @default.
- W223860579 hasAuthorship W223860579A5024264861 @default.
- W223860579 hasAuthorship W223860579A5055231348 @default.
- W223860579 hasAuthorship W223860579A5061036155 @default.
- W223860579 hasAuthorship W223860579A5062612010 @default.
- W223860579 hasBestOaLocation W2238605791 @default.
- W223860579 hasConcept C112705442 @default.
- W223860579 hasConcept C150903083 @default.
- W223860579 hasConcept C178790620 @default.
- W223860579 hasConcept C184651966 @default.
- W223860579 hasConcept C185592680 @default.
- W223860579 hasConcept C207001950 @default.
- W223860579 hasConcept C2778123984 @default.
- W223860579 hasConcept C2780131815 @default.
- W223860579 hasConcept C2910396414 @default.
- W223860579 hasConcept C43617362 @default.
- W223860579 hasConcept C501593827 @default.
- W223860579 hasConcept C55493867 @default.
- W223860579 hasConcept C64778159 @default.
- W223860579 hasConcept C71924100 @default.
- W223860579 hasConcept C77281830 @default.
- W223860579 hasConcept C86803240 @default.
- W223860579 hasConcept C98274493 @default.
- W223860579 hasConceptScore W223860579C112705442 @default.
- W223860579 hasConceptScore W223860579C150903083 @default.
- W223860579 hasConceptScore W223860579C178790620 @default.
- W223860579 hasConceptScore W223860579C184651966 @default.
- W223860579 hasConceptScore W223860579C185592680 @default.
- W223860579 hasConceptScore W223860579C207001950 @default.
- W223860579 hasConceptScore W223860579C2778123984 @default.
- W223860579 hasConceptScore W223860579C2780131815 @default.
- W223860579 hasConceptScore W223860579C2910396414 @default.
- W223860579 hasConceptScore W223860579C43617362 @default.
- W223860579 hasConceptScore W223860579C501593827 @default.
- W223860579 hasConceptScore W223860579C55493867 @default.
- W223860579 hasConceptScore W223860579C64778159 @default.
- W223860579 hasConceptScore W223860579C71924100 @default.
- W223860579 hasConceptScore W223860579C77281830 @default.
- W223860579 hasConceptScore W223860579C86803240 @default.
- W223860579 hasConceptScore W223860579C98274493 @default.
- W223860579 hasIssue "3" @default.
- W223860579 hasLocation W2238605791 @default.
- W223860579 hasLocation W2238605792 @default.
- W223860579 hasOpenAccess W223860579 @default.
- W223860579 hasPrimaryLocation W2238605791 @default.
- W223860579 hasRelatedWork W1491964893 @default.
- W223860579 hasRelatedWork W1989472841 @default.
- W223860579 hasRelatedWork W2004556784 @default.
- W223860579 hasRelatedWork W2051808886 @default.
- W223860579 hasRelatedWork W2069211444 @default.
- W223860579 hasRelatedWork W2143194548 @default.
- W223860579 hasRelatedWork W223860579 @default.
- W223860579 hasRelatedWork W2378945660 @default.
- W223860579 hasRelatedWork W2582907174 @default.
- W223860579 hasRelatedWork W2753834235 @default.
- W223860579 hasVolume "16" @default.
- W223860579 isParatext "false" @default.
- W223860579 isRetracted "false" @default.
- W223860579 magId "223860579" @default.
- W223860579 workType "article" @default.