Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238637024> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2238637024 endingPage "54" @default.
- W2238637024 startingPage "51" @default.
- W2238637024 abstract "From previous and more recent works reviewed in the present paper, it appears that mammalian fetal oocytes face several challenges to survive throughout the stages of meiotic prophase I up to the block at the diplotene/dictyate stage and the primordial follicle assembly. Depending on the period of development and experimental conditions, these oocytes can undergo different forms of programmed cell death (PCD) and cross-talking pathways. We hypothesize that they require the continuous support of growth factors to accomplish the activities required to overcome PCD during prophase I. An extraordinary level of DNA double strand break (DSB) tolerance characterizes oocytes during the first stages of meiotic prophase I. However, the activation of a p63/p53-and PCNA-dependent DNA damage checkpoint, plays a major role in eliminating defective oocytes when they reach the diplotene stage. Before oocytes are enclosed into a primordial follicle, the shortness of nutrients/growth factors might activate protective autophagy but this can turn into their death if starvation is prolonged. Actually, clarifying the relationships among growth factor signalling (mainly AKT cascade), apoptotic and autophagic proteins that seem to coexist in fetal oocytes, could be the key to understanding PCD in these cells." @default.
- W2238637024 created "2016-06-24" @default.
- W2238637024 creator A5025679246 @default.
- W2238637024 creator A5058144246 @default.
- W2238637024 creator A5081657165 @default.
- W2238637024 date "2015-01-01" @default.
- W2238637024 modified "2023-10-18" @default.
- W2238637024 title "Multifaceted programmed cell death in the mammalian fetal ovary" @default.
- W2238637024 cites W1491156367 @default.
- W2238637024 cites W1505126425 @default.
- W2238637024 cites W1969402237 @default.
- W2238637024 cites W1973510581 @default.
- W2238637024 cites W1983319354 @default.
- W2238637024 cites W1994831927 @default.
- W2238637024 cites W1996438022 @default.
- W2238637024 cites W1999301366 @default.
- W2238637024 cites W2000352412 @default.
- W2238637024 cites W2005916933 @default.
- W2238637024 cites W2014976628 @default.
- W2238637024 cites W2016499148 @default.
- W2238637024 cites W2078260033 @default.
- W2238637024 cites W2086655682 @default.
- W2238637024 cites W2086778634 @default.
- W2238637024 cites W2088744498 @default.
- W2238637024 cites W2124379916 @default.
- W2238637024 cites W2135758370 @default.
- W2238637024 cites W2136482301 @default.
- W2238637024 cites W2146522923 @default.
- W2238637024 cites W2151627617 @default.
- W2238637024 cites W2156483686 @default.
- W2238637024 cites W2166374781 @default.
- W2238637024 cites W2288182179 @default.
- W2238637024 cites W47754789 @default.
- W2238637024 doi "https://doi.org/10.1387/ijdb.150063fk" @default.
- W2238637024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26374525" @default.
- W2238637024 hasPublicationYear "2015" @default.
- W2238637024 type Work @default.
- W2238637024 sameAs 2238637024 @default.
- W2238637024 citedByCount "31" @default.
- W2238637024 countsByYear W22386370242016 @default.
- W2238637024 countsByYear W22386370242017 @default.
- W2238637024 countsByYear W22386370242018 @default.
- W2238637024 countsByYear W22386370242019 @default.
- W2238637024 countsByYear W22386370242020 @default.
- W2238637024 countsByYear W22386370242021 @default.
- W2238637024 countsByYear W22386370242022 @default.
- W2238637024 countsByYear W22386370242023 @default.
- W2238637024 crossrefType "journal-article" @default.
- W2238637024 hasAuthorship W2238637024A5025679246 @default.
- W2238637024 hasAuthorship W2238637024A5058144246 @default.
- W2238637024 hasAuthorship W2238637024A5081657165 @default.
- W2238637024 hasBestOaLocation W22386370241 @default.
- W2238637024 hasConcept C104317684 @default.
- W2238637024 hasConcept C148196450 @default.
- W2238637024 hasConcept C190283241 @default.
- W2238637024 hasConcept C196843134 @default.
- W2238637024 hasConcept C203522944 @default.
- W2238637024 hasConcept C2776690073 @default.
- W2238637024 hasConcept C31573885 @default.
- W2238637024 hasConcept C45413362 @default.
- W2238637024 hasConcept C54355233 @default.
- W2238637024 hasConcept C86803240 @default.
- W2238637024 hasConcept C95444343 @default.
- W2238637024 hasConceptScore W2238637024C104317684 @default.
- W2238637024 hasConceptScore W2238637024C148196450 @default.
- W2238637024 hasConceptScore W2238637024C190283241 @default.
- W2238637024 hasConceptScore W2238637024C196843134 @default.
- W2238637024 hasConceptScore W2238637024C203522944 @default.
- W2238637024 hasConceptScore W2238637024C2776690073 @default.
- W2238637024 hasConceptScore W2238637024C31573885 @default.
- W2238637024 hasConceptScore W2238637024C45413362 @default.
- W2238637024 hasConceptScore W2238637024C54355233 @default.
- W2238637024 hasConceptScore W2238637024C86803240 @default.
- W2238637024 hasConceptScore W2238637024C95444343 @default.
- W2238637024 hasIssue "1-2-3" @default.
- W2238637024 hasLocation W22386370241 @default.
- W2238637024 hasLocation W22386370242 @default.
- W2238637024 hasOpenAccess W2238637024 @default.
- W2238637024 hasPrimaryLocation W22386370241 @default.
- W2238637024 hasRelatedWork W2012224340 @default.
- W2238637024 hasRelatedWork W2028304108 @default.
- W2238637024 hasRelatedWork W2054815464 @default.
- W2238637024 hasRelatedWork W2084880710 @default.
- W2238637024 hasRelatedWork W2355246966 @default.
- W2238637024 hasRelatedWork W2890156259 @default.
- W2238637024 hasRelatedWork W2912385559 @default.
- W2238637024 hasRelatedWork W2993499003 @default.
- W2238637024 hasRelatedWork W3149757538 @default.
- W2238637024 hasRelatedWork W843168755 @default.
- W2238637024 hasVolume "59" @default.
- W2238637024 isParatext "false" @default.
- W2238637024 isRetracted "false" @default.
- W2238637024 magId "2238637024" @default.
- W2238637024 workType "article" @default.