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• W223868778 abstract "An excitatory amino acid, possibly L-glutamate, is supposed to act as a neurotransmitter at the inner hair cell (IHC)-afferent fiber synapses in the cochlea. In a previous study, we have used an electrophysiological approach to investigate at this level the presence of the two major types of glutamate receptors, namely N-Methyl-D-Aspartate (NMDA) and non-NMDA (AMPA and/or kainate) receptors. Our results demonstrated that both types of receptors are probably present is the cochlea and are involved in different physiological responses: the NMDA receptors being activated only at high intensity of sound stimulations. Histological examinations of the cochleas perfused with glutamate agonists support these conclusions. Actually, an acute excitotoxic effects at the level of radial dendrites under the IHCs was only observed with non-NMDA agonists. It is striking to compare the similarity of histological damage after acute exposure to kainate or AMPA with those observed after ischemic events. In all cases, the same type of dendritic swelling occurred under IHCs, and this swelling could be prevented by a prior application of a selective non-NMDA antagonist (DNQX). Altogether, these results strongly support the hypothesis that L-glutamate or related congener is the IHC neurotransmitter." @default.
• W223868778 created "2016-06-24" @default.
• W223868778 creator A5038870188 @default.
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• W223868778 date "1992-01-01" @default.
• W223868778 modified "2023-09-29" @default.
• W223868778 title "Selective Glutamate Antagonists Block the Excitotoxicity Caused Either by Glutamate Agonists or by Ischemia" @default.
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• W223868778 doi "https://doi.org/10.1016/b978-0-08-041847-6.50072-1" @default.
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