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• W2238698976 startingPage "374" @default.
• W2238698976 abstract "The modulation of voltage-gated Na + currents in isolated somata of dorsal unpaired median (DUM) neurons of the cockroach Periplaneta americana was investigated using the patch-clamp technique. The neuropeptide Neurohormone D (NHD), which belongs to the family of adipokinetic hormones, reversibly reduced the Na + current in concentration-dependent manner (1 pM to 10 nM). At 10 nM, NHD caused an attenuation of the maximum of current-voltage ( I-V) relation for peak currents by 23 ± 6%. An analysis of NHD action on current kinetics in terms of the Hodgkin-Huxley formalism revealed that NHD reduces the time constant of inactivation, whereas steady-state activation and inactivation as well as the time constant of activation were not affected. In addition, NHD prolonged the recovery from inactivation. The cAMP analogue 8-bromo-cAMP, forskolin, and the catalytic subunit of protein kinase A mimicked the action of NHD. Furthermore, preincubation of cells with the protein kinase A inhibitor KT 5720 abolished the action of NHD. Thus NHD seems to modify the Na + current via channel phosphorylation by protein kinase A. Activation of protein kinase C by oleoylacetylglycerol (OAG) also reduced the Na + current, but it did not occlude the action of NHD. On the other hand, inhibition of protein kinase C by chelerythrine or Gö 6976 did not essentially impair the NHD effects." @default.
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• W2238698976 date "2001-01-01" @default.
• W2238698976 modified "2023-10-04" @default.
• W2238698976 title "Peptidergic Modulation of an Insect Na⁺Current: Role of Protein Kinase A and Protein Kinase C" @default.
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• W2238698976 doi "https://doi.org/10.1152/jn.2001.85.1.374" @default.
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