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• W2238779013 abstract "Both (19)F MRI and optical imaging are powerful noninvasive molecular imaging modalities in biomedical applications. To integrate these two complementary imaging modalities, the design and synthesis of a novel (19)F MRI/fluorescence dual-modal imaging agent is reported herein. Through Sonogashira coupling reaction between the fluorinated phenylacetylene and 1,2,4,5-tetraiodobenzene, a fluorophore with 48 symmetrical fluorines at its periphery was constructed with high efficacy. High aqueous solubility was achieved by PEGylation of the fluorophore with monodisperse PEGs. However, an unexpected self-assembly of the PEGylated amphiphilic fluorophore in water turned off the (19)F NMR signal. However, hydrogenation of the triple bonds or introduction of branched monodisperse PEGs was able to efficiently tune the self-assembly, resulting in the turning on of the (19)F NMR signal. One of these amphiphiles combines the advantages of label-free fluorescence, high (19)F MRI sensitivity, biocompatibility, and excellent aqueous solubility. The results demonstrate the great potential of such amphiphiles for real-time (19)F MRI and fluorescence dual-modality imaging." @default.
• W2238779013 created "2016-06-24" @default.
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• W2238779013 date "2015-06-05" @default.
• W2238779013 modified "2023-10-14" @default.
• W2238779013 title "Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly" @default.
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• W2238779013 doi "https://doi.org/10.1021/acs.joc.5b00810" @default.
• W2238779013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26016450" @default.
• W2238779013 hasPublicationYear "2015" @default.
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