FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238806311> ?p ?o ?g. }

• W2238806311 endingPage "282" @default.
• W2238806311 startingPage "267" @default.
• W2238806311 abstract "Memory CD4(+) T cells promote protective humoral immunity; however, how memory T cells acquire this activity remains unclear. This study demonstrates that CD4(+) T cells develop into antigen-specific memory T cells that can promote the terminal differentiation of memory B cells far more effectively than their naive T-cell counterparts. Memory T cell development requires the transcription factor B-cell lymphoma 6 (Bcl6), which is known to direct T-follicular helper (Tfh) cell differentiation. However, unlike Tfh cells, memory T cell development did not require germinal center B cells. Curiously, memory T cells that develop in the absence of cognate B cells cannot promote memory B-cell recall responses and this defect was accompanied by down-regulation of genes associated with homeostasis and activation and up-regulation of genes inhibitory for T-cell responses. Although memory T cells display phenotypic and genetic signatures distinct from Tfh cells, both had in common the expression of a group of genes associated with metabolic pathways. This gene expression profile was not shared to any great extent with naive T cells and was not influenced by the absence of cognate B cells during memory T cell development. These results suggest that memory T cell development is programmed by stepwise expression of gatekeeper genes through serial interactions with different types of antigen-presenting cells, first licensing the memory lineage pathway and subsequently facilitating the functional development of memory T cells. Finally, we identified Gdpd3 as a candidate genetic marker for memory T cells." @default.
• W2238806311 created "2016-06-24" @default.
• W2238806311 creator A5020620902 @default.
• W2238806311 creator A5021370574 @default.
• W2238806311 creator A5022824551 @default.
• W2238806311 creator A5029542818 @default.
• W2238806311 creator A5035894578 @default.
• W2238806311 creator A5045517196 @default.
• W2238806311 creator A5053435471 @default.
• W2238806311 creator A5066057500 @default.
• W2238806311 creator A5074983744 @default.
• W2238806311 creator A5079901434 @default.
• W2238806311 creator A5084275731 @default.
• W2238806311 date "2015-12-29" @default.
• W2238806311 modified "2023-09-24" @default.
• W2238806311 title "CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation" @default.
• W2238806311 cites W1545139625 @default.
• W2238806311 cites W1556459637 @default.
• W2238806311 cites W1583142497 @default.
• W2238806311 cites W1585963843 @default.
• W2238806311 cites W1610017743 @default.
• W2238806311 cites W1612160402 @default.
• W2238806311 cites W1901606394 @default.
• W2238806311 cites W1910121196 @default.
• W2238806311 cites W1973274031 @default.
• W2238806311 cites W1973614663 @default.
• W2238806311 cites W1974127378 @default.
• W2238806311 cites W1981480494 @default.
• W2238806311 cites W1981732254 @default.
• W2238806311 cites W1985173426 @default.
• W2238806311 cites W1991497659 @default.
• W2238806311 cites W1992949591 @default.
• W2238806311 cites W1997064574 @default.
• W2238806311 cites W1997735093 @default.
• W2238806311 cites W1998691315 @default.
• W2238806311 cites W1999324987 @default.
• W2238806311 cites W2000919345 @default.
• W2238806311 cites W2001775594 @default.
• W2238806311 cites W2002548381 @default.
• W2238806311 cites W2008540730 @default.
• W2238806311 cites W2017037510 @default.
• W2238806311 cites W2017219476 @default.
• W2238806311 cites W2017433337 @default.
• W2238806311 cites W2018476626 @default.
• W2238806311 cites W2022930162 @default.
• W2238806311 cites W2024460967 @default.
• W2238806311 cites W2034360108 @default.
• W2238806311 cites W2037073876 @default.
• W2238806311 cites W2037088576 @default.
• W2238806311 cites W2038976543 @default.
• W2238806311 cites W2039031880 @default.
• W2238806311 cites W2041635246 @default.
• W2238806311 cites W2046730243 @default.
• W2238806311 cites W2052103041 @default.
• W2238806311 cites W2053164685 @default.
• W2238806311 cites W2056703680 @default.
• W2238806311 cites W2057146995 @default.
• W2238806311 cites W2057698592 @default.
• W2238806311 cites W2064782766 @default.
• W2238806311 cites W2065338955 @default.
• W2238806311 cites W2066489069 @default.
• W2238806311 cites W2071969437 @default.
• W2238806311 cites W2074065268 @default.
• W2238806311 cites W2074309287 @default.
• W2238806311 cites W2075175827 @default.
• W2238806311 cites W2076236096 @default.
• W2238806311 cites W2076795211 @default.
• W2238806311 cites W2077522176 @default.
• W2238806311 cites W2082871926 @default.
• W2238806311 cites W2083046463 @default.
• W2238806311 cites W2089497292 @default.
• W2238806311 cites W2095939112 @default.
• W2238806311 cites W2097065948 @default.
• W2238806311 cites W2097289038 @default.
• W2238806311 cites W2100856280 @default.
• W2238806311 cites W2106298979 @default.
• W2238806311 cites W2110043839 @default.
• W2238806311 cites W2113327004 @default.
• W2238806311 cites W2113847305 @default.
• W2238806311 cites W2114380262 @default.
• W2238806311 cites W2119856031 @default.
• W2238806311 cites W2123910031 @default.
• W2238806311 cites W2132444785 @default.
• W2238806311 cites W2132838609 @default.
• W2238806311 cites W2133707124 @default.
• W2238806311 cites W2134257200 @default.
• W2238806311 cites W2134342374 @default.
• W2238806311 cites W2136006589 @default.
• W2238806311 cites W2136442347 @default.
• W2238806311 cites W2139565733 @default.
• W2238806311 cites W2141458291 @default.
• W2238806311 cites W2146604395 @default.
• W2238806311 cites W2147450297 @default.
• W2238806311 cites W2151450394 @default.
• W2238806311 cites W2157669002 @default.
• W2238806311 cites W2162068902 @default.
• W2238806311 cites W2164373720 @default.
• W2238806311 cites W2172215633 @default.

• next