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• W2238830875 abstract "A one-pot and two-step reaction of four components, including aldehydes, Fmoc-protected α-amino acid, isocyanide, and soluble polymer-supported 4-fluoro-3-amino benzoate ester, was developed for an efficient synthesis of dihydroquinoxalinones under microwave irradiation. Fmoc deprotection followed by intramolecular cyclization of the diamide gave a facile access to novel bicyclic quinoxalin-2-ones. On the basis of this approach, a new route to synthesize this privileged scaffold from the diamide intermediate was designed and accomplished with high yields. Use of multicomponent reaction (MCR) has been shown to display a good functional group tolerance, while the product isolation and purification is straightforward by precipitation and washings. Current library discusses the synthesis and diversification of 21 compounds produced using this strategy." @default.
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• W2238830875 date "2015-06-29" @default.
• W2238830875 modified "2023-09-24" @default.
• W2238830875 title "Microwave-Assisted Multicomponent Synthesis of Dihydroquinoxalinones on Soluble Polymer Support" @default.
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• W2238830875 doi "https://doi.org/10.1021/acscombsci.5b00053" @default.
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