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- W2238831297 abstract "The search for a single silver bullet for the treatment of cancer has now been overshadowed by the identification of multiple therapeutic targets unique to each malignancy and even to each patient. In recent years, autophagy has emerged as one such therapeutic target. In response to both therapeutic and oncogenic stress, cancer cells upregulate and demonstrate an increased dependence upon this intracellular recycling process. Particularly in malignancies that currently lack targeted therapeutic options, autophagy inhibitors are the next hopeful prospects for the treatment of this disease. In this review, we discuss the rapid evolution of autophagy inhibitors from early lysosomotropic agents to next-generation lysosome-targeted drugs and beyond." @default.
- W2238831297 created "2016-06-24" @default.
- W2238831297 creator A5037005533 @default.
- W2238831297 creator A5057637741 @default.
- W2238831297 date "2016-01-01" @default.
- W2238831297 modified "2023-10-11" @default.
- W2238831297 title "Leaving the lysosome behind: novel developments in autophagy inhibition" @default.
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- W2238831297 doi "https://doi.org/10.4155/fmc.15.166" @default.
- W2238831297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4886745" @default.
- W2238831297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26689099" @default.
- W2238831297 hasPublicationYear "2016" @default.
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