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• W2238851296 endingPage "93" @default.
• W2238851296 startingPage "83" @default.
• W2238851296 abstract "Depression is a highly familial and a heritable illness that is more prevalent in the biological offspring of the depressed individuals than in the general population. In a 3-generation, 30-year, longitudinal study of individuals at either a high(HR) or a low(LR) familial risk for depression, we previously showed cortical thinning in the right hemisphere was an endophenotype for the familial risk. In this study, we assessed whether the effects of familial risk were modulated by the serotonin-transporter-linked polymorphic region (5-HTTLPR). We measured cortical thickness using MRI of the brain and associated it with 5-HTTLPR polymorphism in 76 HR and 53 LR individuals. We studied the effects of genotype and gene-by-risk interaction on cortical thickness while controlling for the confounding effects of age and gender, and for the familial relatedness by applying a variance component model with random effects for genotype. The results showed significant effects of gene-by-risk interaction on thickness: The s allele was associated with thinner cortex in the LR individuals whereas with thicker cortex in the HR individuals. The opposing gene effects across the two risk groups were likely due to either epistatic effects and/or differing modulation of the neural plasticity by the altered 5-HT signaling in utero." @default.
• W2238851296 created "2016-06-24" @default.
• W2238851296 creator A5007729877 @default.
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• W2238851296 creator A5061353361 @default.
• W2238851296 creator A5061363473 @default.
• W2238851296 creator A5066527489 @default.
• W2238851296 date "2016-02-01" @default.
• W2238851296 modified "2023-10-14" @default.
• W2238851296 title "Serotonin signaling modulates the effects of familial risk for depression on cortical thickness" @default.
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