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• W2238860152 endingPage "132" @default.
• W2238860152 startingPage "126" @default.
• W2238860152 abstract "BACKGROUND: The analgesic action of botulinum neurotoxin type A (BoNTA) has been linked to the blockade of peripheral release of neuropeptides and neurotransmitters in animal models; however, there is no direct evidence of this in humans. OBJECTIVES: To investigate the effect of BoNTA on glutamate release in humans, using an experimental model of pain and sensitization provoked by capsaicin plus mild heat. METHODS: Twelve healthy volunteers (six men, six women) were pretreated with BoNTA (10 U) on the volar forearm and with a saline control on the contralateral side. Dermal microdialysis was applied one week later to collect interstitial samples before and after the application of a capsaicin patch (8%) plus mild heat (40°C/60 min) to provoke glutamate release, pain and vasodilation. Samples were collected every hour for 3 h using linear microdialysis probes (10 mm, 100 kD). Dialysate was analyzed for glutamate concentration. Pain intensity and skin vasomotor reactions (temperature and blood flow changes) were also recorded. RESULTS: BoNTA significantly reduced glutamate release compared with saline (P<0.05). The provoked pain intensity was lower in the BoNTA-pretreated arm (P<0.01). The reduction in pain scores was not correlated with glutamate level. Cutaneous blood flow (P<0.05), but not cutaneous temperature (P≥0.05), was significantly reduced by BoNTA. There was a correlation between glutamate level and skin blood flow (r=0.58/P<0.05) but not skin temperature (P≥0.05). No differences according to sex were observed in any response. CONCLUSIONS: The present study provided the first direct evidence supporting the inhibitory effect of BoNTA on glutamate release in human skin, which is potentially responsible for some of the analgesic action of BoNTA." @default.
• W2238860152 created "2016-06-24" @default.
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• W2238860152 date "2014-01-01" @default.
• W2238860152 modified "2023-09-26" @default.
• W2238860152 title "Blockade of Glutamate Release by Botulinum Neurotoxin Type A in Humans: A Dermal Microdialysis Study" @default.
• W2238860152 cites W1511198581 @default.
• W2238860152 cites W1965298791 @default.
• W2238860152 cites W1965570028 @default.
• W2238860152 cites W1965836027 @default.
• W2238860152 cites W1967166816 @default.
• W2238860152 cites W1968960893 @default.
• W2238860152 cites W1972810592 @default.
• W2238860152 cites W1972855387 @default.
• W2238860152 cites W1973039159 @default.
• W2238860152 cites W1975770638 @default.
• W2238860152 cites W1980008189 @default.
• W2238860152 cites W1982373142 @default.
• W2238860152 cites W1984109801 @default.
• W2238860152 cites W1987192367 @default.
• W2238860152 cites W1990329083 @default.
• W2238860152 cites W1999388027 @default.
• W2238860152 cites W1999803273 @default.
• W2238860152 cites W2004994969 @default.
• W2238860152 cites W2007410119 @default.
• W2238860152 cites W2013024935 @default.
• W2238860152 cites W2015477988 @default.
• W2238860152 cites W2017189491 @default.
• W2238860152 cites W2019686332 @default.
• W2238860152 cites W2022302694 @default.
• W2238860152 cites W2023570957 @default.
• W2238860152 cites W2027315167 @default.
• W2238860152 cites W2027336204 @default.
• W2238860152 cites W2034164531 @default.
• W2238860152 cites W2035750459 @default.
• W2238860152 cites W2037031094 @default.
• W2238860152 cites W2038833296 @default.
• W2238860152 cites W2043661731 @default.
• W2238860152 cites W2048499176 @default.
• W2238860152 cites W2053277833 @default.
• W2238860152 cites W2058937602 @default.
• W2238860152 cites W2060980826 @default.
• W2238860152 cites W2064501211 @default.
• W2238860152 cites W2066871405 @default.
• W2238860152 cites W2069865837 @default.
• W2238860152 cites W2071641378 @default.
• W2238860152 cites W2073003556 @default.
• W2238860152 cites W2073224536 @default.
• W2238860152 cites W2080945262 @default.
• W2238860152 cites W2085970203 @default.
• W2238860152 cites W2087985521 @default.
• W2238860152 cites W2089213711 @default.
• W2238860152 cites W2094479806 @default.
• W2238860152 cites W2094586381 @default.
• W2238860152 cites W2094955398 @default.
• W2238860152 cites W2098458973 @default.
• W2238860152 cites W2103655434 @default.
• W2238860152 cites W2103797832 @default.
• W2238860152 cites W2116090395 @default.
• W2238860152 cites W2123166542 @default.
• W2238860152 cites W2129974957 @default.
• W2238860152 cites W2132968602 @default.
• W2238860152 cites W2135120074 @default.
• W2238860152 cites W2142323737 @default.
• W2238860152 cites W2144499458 @default.
• W2238860152 cites W2150224367 @default.
• W2238860152 cites W2151903769 @default.
• W2238860152 cites W2153751480 @default.
• W2238860152 cites W2154152084 @default.
• W2238860152 cites W2157433559 @default.
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• W2238860152 cites W2167481964 @default.
• W2238860152 cites W2167719770 @default.
• W2238860152 cites W2169972151 @default.
• W2238860152 cites W2187766168 @default.
• W2238860152 cites W2314484846 @default.
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• W2238860152 doi "https://doi.org/10.1155/2014/410415" @default.
• W2238860152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4158957" @default.
• W2238860152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24851237" @default.
• W2238860152 hasPublicationYear "2014" @default.
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