FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238862642> ?p ?o ?g. }

• W2238862642 abstract "Brain-derived neurotrophic factor (BDNF) mediates neuron growth and is regulated by adenylyl cyclases (ACs). Mice lacking AC1/8 (DKO) have a basal reduction in the dendritic complexity of medium spiny neurons in the caudate putamen and demonstrate increased neurotoxicity in the striatum following acute neonatal ethanol exposure compared to wild type (WT) controls, suggesting a compromise in BDNF regulation under varying conditions. Although neonatal ethanol exposure can negatively impact BDNF expression, little is known about the effect on BDNF receptor activation and its downstream signaling, including Akt activation, an established neuroprotective pathway. Therefore, here we determined the effects of AC1/8 deletion and neonatal ethanol administration on BDNF and proBDNF protein expression, and activation of tropomyosin-related kinase B (TrkB), Akt, ERK1/2, and PLCγ. WT and DKO mice were treated with a single dose of 2.5 g/kg ethanol or saline at postnatal days 5-7 to model late-gestational alcohol exposure. Striatal and cortical tissues were analyzed using a BDNF enzyme-linked immunosorbent assay or immunoblotting for proBDNF, phosphorylated and total TrkB, Akt, ERK1/2, and PLCɣ1. Neither postnatal ethanol exposure nor AC1/8 deletion affected total BDNF protein expression at any time point in either region examined. Neonatal ethanol increased the expression of proBDNF protein in the striatum of WT mice 6, 24, and 48 h after exposure, with DKO mice demonstrating a reduction in proBDNF expression 6 h after exposure. Six and 24 h after ethanol administration, phosphorylation of full-length TrkB in the striatum was significantly reduced in WT mice, but was significantly increased in DKO mice only at 24 h. Interestingly, 48 h after ethanol, both WT and DKO mice demonstrated a reduction in phosphorylated full-length TrkB. In addition, Akt and PLCɣ1 phosphorylation was also decreased in ethanol-treated DKO mice 48 h after injection. These data demonstrate dysregulation of a potential survival pathway in the AC1/8 knockout mice following early-life ethanol exposure." @default.
• W2238862642 created "2016-06-24" @default.
• W2238862642 creator A5010527305 @default.
• W2238862642 creator A5013899443 @default.
• W2238862642 creator A5049437745 @default.
• W2238862642 creator A5062790470 @default.
• W2238862642 date "2016-03-01" @default.
• W2238862642 modified "2023-09-26" @default.
• W2238862642 title "Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder" @default.
• W2238862642 cites W1496088120 @default.
• W2238862642 cites W1892553999 @default.
• W2238862642 cites W1969848504 @default.
• W2238862642 cites W1971812347 @default.
• W2238862642 cites W1973376874 @default.
• W2238862642 cites W1977156046 @default.
• W2238862642 cites W1985768896 @default.
• W2238862642 cites W1987092343 @default.
• W2238862642 cites W1987757645 @default.
• W2238862642 cites W1988978154 @default.
• W2238862642 cites W1995341142 @default.
• W2238862642 cites W2003665687 @default.
• W2238862642 cites W2010843703 @default.
• W2238862642 cites W2011050809 @default.
• W2238862642 cites W2011524968 @default.
• W2238862642 cites W2012199594 @default.
• W2238862642 cites W2012423618 @default.
• W2238862642 cites W2014871698 @default.
• W2238862642 cites W2016098326 @default.
• W2238862642 cites W2017641447 @default.
• W2238862642 cites W2018571267 @default.
• W2238862642 cites W2018645817 @default.
• W2238862642 cites W2019391453 @default.
• W2238862642 cites W2021552563 @default.
• W2238862642 cites W2022800308 @default.
• W2238862642 cites W2024983072 @default.
• W2238862642 cites W2026561007 @default.
• W2238862642 cites W2028787364 @default.
• W2238862642 cites W2031107029 @default.
• W2238862642 cites W2039137237 @default.
• W2238862642 cites W2046546217 @default.
• W2238862642 cites W2047937248 @default.
• W2238862642 cites W2049245451 @default.
• W2238862642 cites W2049667989 @default.
• W2238862642 cites W2065958702 @default.
• W2238862642 cites W2068608248 @default.
• W2238862642 cites W2071694094 @default.
• W2238862642 cites W2072516661 @default.
• W2238862642 cites W2073454274 @default.
• W2238862642 cites W2079108515 @default.
• W2238862642 cites W2080527942 @default.
• W2238862642 cites W2084374294 @default.
• W2238862642 cites W2086528223 @default.
• W2238862642 cites W2086835104 @default.
• W2238862642 cites W2088804493 @default.
• W2238862642 cites W2089036308 @default.
• W2238862642 cites W2094023516 @default.
• W2238862642 cites W2113122815 @default.
• W2238862642 cites W2113336683 @default.
• W2238862642 cites W2116603478 @default.
• W2238862642 cites W2130202356 @default.
• W2238862642 cites W2131612987 @default.
• W2238862642 cites W2139565721 @default.
• W2238862642 cites W2143603642 @default.
• W2238862642 cites W2152172842 @default.
• W2238862642 cites W2161586708 @default.
• W2238862642 cites W2162665706 @default.
• W2238862642 cites W2165471234 @default.
• W2238862642 cites W2168323093 @default.
• W2238862642 cites W2275293999 @default.
• W2238862642 cites W2297168669 @default.
• W2238862642 cites W4232862622 @default.
• W2238862642 cites W95485003 @default.
• W2238862642 doi "https://doi.org/10.1016/j.alcohol.2015.11.008" @default.
• W2238862642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5434701" @default.
• W2238862642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26992697" @default.
• W2238862642 hasPublicationYear "2016" @default.
• W2238862642 type Work @default.
• W2238862642 sameAs 2238862642 @default.
• W2238862642 citedByCount "2" @default.
• W2238862642 countsByYear W22388626422019 @default.
• W2238862642 countsByYear W22388626422021 @default.
• W2238862642 crossrefType "journal-article" @default.
• W2238862642 hasAuthorship W2238862642A5010527305 @default.
• W2238862642 hasAuthorship W2238862642A5013899443 @default.
• W2238862642 hasAuthorship W2238862642A5049437745 @default.
• W2238862642 hasAuthorship W2238862642A5062790470 @default.
• W2238862642 hasBestOaLocation W22388626422 @default.
• W2238862642 hasConcept C11960822 @default.
• W2238862642 hasConcept C126322002 @default.
• W2238862642 hasConcept C134018914 @default.
• W2238862642 hasConcept C160539049 @default.
• W2238862642 hasConcept C170493617 @default.
• W2238862642 hasConcept C185592680 @default.
• W2238862642 hasConcept C24998067 @default.
• W2238862642 hasConcept C2778790584 @default.
• W2238862642 hasConcept C2779178603 @default.
• W2238862642 hasConcept C2779491297 @default.
• W2238862642 hasConcept C2780062018 @default.
• W2238862642 hasConcept C29730261 @default.
• W2238862642 hasConcept C513476851 @default.

• next