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- W2238874763 abstract "In the marine bacterium Vibrio fischeri two intercellular homoserine-Iactonesignal molecules (luxI-dependent 30C6-HSL and the ainS-dependent C8-HSL) and thetranscriptional activator LuxR regulate the luminescence system in a cell-densitydependent manner by a process termed quorum sensing. In this study, five additionalproteins whose production is regulated by quorum sensing are described, and the genesencoding four of the five proteins, denoted as QsrP, RibB, QsrV, and AcfA, are analyzed.Each protein is positively regulated by 30C6-HSL and LuxR and negatively regulated atlow population density by C8-HSL. Probable LuxR/autoinducer binding sites are foundin the promoter region of each. QsrP and RibB are encoded monocistronically, whereasAcfA and QsrV appear to be encoded by a two-gene operon. On the basis of sequencesimilarity to proteins of known function from other organisms, RibB is believed to be anenzyme that catalyzes the transformation of ribulose 5-phosphate to 3,4-dihydroxy-2-butanone 4-phosphate, a precursor for the xylene ring of riboflavin; AcfA is believed tobe a pilus subunit; and the functions of QsrP and QsrV are unknown at this time. A qsrPmutant was reduced in its ability to colonize its symbiotic partner, Euprymna scolopeswhen placed in competition with the parent strain. On the other hand, a mutant strain ofV. fischeri containing an insertion in acfA, which is believed to be polar with respect toqsrV, displayed enhanced colonization competence in a competition assay. A ribBmutant grew well on media not supplemented with additional riboflavin and displayednormal induction of luminescence. Both phenotypes suggest that the lack of a functionalribB gene is complemented by another gene of similar function in the mutant. Orienteddivergently from acfA are open reading frames that code for two putative proteins that aresimilar in sequence to members of the LysR family of transcriptional regulators.Organization of the two divergent sets of genes and the shared promoter region suggeststhat transcription of acfA and qsrV may be regulated by one or both of these divergentlytranscribed proteins. This work defines a quorum-sensing regulon in V. fischeri. Amodel describing its regulation is presented." @default.
- W2238874763 created "2016-06-24" @default.
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- W2238874763 date "1999-01-01" @default.
- W2238874763 modified "2023-09-23" @default.
- W2238874763 title "The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinducer/LuxR regulatory circuit" @default.
- W2238874763 doi "https://doi.org/10.1575/1912/4718" @default.
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