Matches in SemOpenAlex for { <https://semopenalex.org/work/W2238893464> ?p ?o ?g. }
- W2238893464 endingPage "776" @default.
- W2238893464 startingPage "761" @default.
- W2238893464 abstract "Purpose: 3 He ions may hold great potential for clinical therapy because of both their physical and biological properties. In this study, the authors investigated the physical properties, i.e., the depth‐dose curves from primary and secondary particles, and the energy distributions of helium ( 3 He) ions. A relative biological effectiveness (RBE) model was applied to assess the biological effectiveness on survival of multiple cell lines. Methods: In light of the lack of experimental measurements and cross sections, the authors used Monte Carlo methods to study the energy deposition of 3 He ions. The transport of 3 He ions in water was simulated by using three Monte Carlo codes— fluka , geant4 , and mcnpx —for incident beams with Gaussian energy distributions with average energies of 527 and 699 MeV and a full width at half maximum of 3.3 MeV in both cases. The RBE of each was evaluated by using the repair‐misrepair‐fixation model. In all of the simulations with each of the three Monte Carlo codes, the same geometry and primary beam parameters were used. Results: Energy deposition as a function of depth and energy spectra with high resolution was calculated on the central axis of the beam. Secondary proton dose from the primary 3 He beams was predicted quite differently by the three Monte Carlo systems. The predictions differed by as much as a factor of 2. Microdosimetric parameters such as dose mean lineal energy ( y D ), frequency mean lineal energy ( y F ), and frequency mean specific energy ( z F ) were used to characterize the radiation beam quality at four depths of the Bragg curve. Calculated RBE values were close to 1 at the entrance, reached on average 1.8 and 1.6 for prostate and head and neck cancer cell lines at the Bragg peak for both energies, but showed some variations between the different Monte Carlo codes. Conclusions: Although the Monte Carlo codes provided different results in energy deposition and especially in secondary particle production (most of the differences between the three codes were observed close to the Bragg peak, where the energy spectrum broadens), the results in terms of RBE were generally similar." @default.
- W2238893464 created "2016-06-24" @default.
- W2238893464 creator A5001445981 @default.
- W2238893464 creator A5021964985 @default.
- W2238893464 creator A5032433695 @default.
- W2238893464 creator A5037851639 @default.
- W2238893464 creator A5041943880 @default.
- W2238893464 creator A5051018350 @default.
- W2238893464 creator A5052523510 @default.
- W2238893464 creator A5080511265 @default.
- W2238893464 creator A5087167680 @default.
- W2238893464 date "2016-01-14" @default.
- W2238893464 modified "2023-10-12" @default.
- W2238893464 title "Monte Carlo simulations of<sup>3</sup>He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness" @default.
- W2238893464 cites W1482774800 @default.
- W2238893464 cites W1923055195 @default.
- W2238893464 cites W1961932368 @default.
- W2238893464 cites W1974260179 @default.
- W2238893464 cites W1982330708 @default.
- W2238893464 cites W1984679632 @default.
- W2238893464 cites W1994000794 @default.
- W2238893464 cites W1997817263 @default.
- W2238893464 cites W2005391728 @default.
- W2238893464 cites W2006498677 @default.
- W2238893464 cites W2019728158 @default.
- W2238893464 cites W2022278632 @default.
- W2238893464 cites W2042499995 @default.
- W2238893464 cites W2051696195 @default.
- W2238893464 cites W2054936929 @default.
- W2238893464 cites W2059158263 @default.
- W2238893464 cites W2078207423 @default.
- W2238893464 cites W2095674520 @default.
- W2238893464 cites W2096372837 @default.
- W2238893464 cites W2098443648 @default.
- W2238893464 cites W2113777563 @default.
- W2238893464 cites W2119760747 @default.
- W2238893464 cites W2119846428 @default.
- W2238893464 cites W2128066858 @default.
- W2238893464 cites W2129493402 @default.
- W2238893464 cites W2130759927 @default.
- W2238893464 cites W2131712508 @default.
- W2238893464 cites W2133808237 @default.
- W2238893464 cites W2139535302 @default.
- W2238893464 cites W2144084582 @default.
- W2238893464 cites W2160994657 @default.
- W2238893464 cites W2266637648 @default.
- W2238893464 cites W2576433130 @default.
- W2238893464 cites W3097364771 @default.
- W2238893464 cites W4240582468 @default.
- W2238893464 cites W75212156 @default.
- W2238893464 doi "https://doi.org/10.1118/1.4939440" @default.
- W2238893464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26843239" @default.
- W2238893464 hasPublicationYear "2016" @default.
- W2238893464 type Work @default.
- W2238893464 sameAs 2238893464 @default.
- W2238893464 citedByCount "13" @default.
- W2238893464 countsByYear W22388934642016 @default.
- W2238893464 countsByYear W22388934642017 @default.
- W2238893464 countsByYear W22388934642018 @default.
- W2238893464 countsByYear W22388934642019 @default.
- W2238893464 countsByYear W22388934642020 @default.
- W2238893464 countsByYear W22388934642021 @default.
- W2238893464 countsByYear W22388934642022 @default.
- W2238893464 crossrefType "journal-article" @default.
- W2238893464 hasAuthorship W2238893464A5001445981 @default.
- W2238893464 hasAuthorship W2238893464A5021964985 @default.
- W2238893464 hasAuthorship W2238893464A5032433695 @default.
- W2238893464 hasAuthorship W2238893464A5037851639 @default.
- W2238893464 hasAuthorship W2238893464A5041943880 @default.
- W2238893464 hasAuthorship W2238893464A5051018350 @default.
- W2238893464 hasAuthorship W2238893464A5052523510 @default.
- W2238893464 hasAuthorship W2238893464A5080511265 @default.
- W2238893464 hasAuthorship W2238893464A5087167680 @default.
- W2238893464 hasConcept C104293457 @default.
- W2238893464 hasConcept C105795698 @default.
- W2238893464 hasConcept C111337013 @default.
- W2238893464 hasConcept C11928243 @default.
- W2238893464 hasConcept C120665830 @default.
- W2238893464 hasConcept C121332964 @default.
- W2238893464 hasConcept C145148216 @default.
- W2238893464 hasConcept C168834538 @default.
- W2238893464 hasConcept C184779094 @default.
- W2238893464 hasConcept C185544564 @default.
- W2238893464 hasConcept C19499675 @default.
- W2238893464 hasConcept C2779244869 @default.
- W2238893464 hasConcept C2989005 @default.
- W2238893464 hasConcept C30475298 @default.
- W2238893464 hasConcept C33923547 @default.
- W2238893464 hasConcept C54516573 @default.
- W2238893464 hasConcept C62520636 @default.
- W2238893464 hasConcept C71924100 @default.
- W2238893464 hasConcept C75088862 @default.
- W2238893464 hasConceptScore W2238893464C104293457 @default.
- W2238893464 hasConceptScore W2238893464C105795698 @default.
- W2238893464 hasConceptScore W2238893464C111337013 @default.
- W2238893464 hasConceptScore W2238893464C11928243 @default.
- W2238893464 hasConceptScore W2238893464C120665830 @default.
- W2238893464 hasConceptScore W2238893464C121332964 @default.