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- W2238981562 abstract "Objective To explore the effects of positive end-expiratory pressure (PEEP) on the oxygenation and shunt fraction during ventilation with solitary lung in open thoracic surgery. Methods Sixty patients (42 males and 18 females, aged 38-72 years, American Society of Anesthesiologist classification Ⅰ-Ⅱ) received lung lobectomy from Jun. to Aug. 2010 were randomly divided into 2 groups (n=30). The patients in group A received solitary lung intermittent positive pressure ventilation (IPPV), and those in group B received solitary lung IPPV combined with PEEP (5cmH2O). The arterial blood gas analysis, pulmonary artery pressure (PAP), mean arterial pressure (MAP), heart rate (HR), arterial partial pressure of oxygen (PaO2) and mixed venous oxygen saturation (SvO2) were monitored and recorded in both groups at the following time points: horizontal position two-lung ventilation (T1), lateral position two-lung ventilation 10 minutes (T2), solitary lung ventilation 10 minutes (T3) and solitary lung ventilation 30 minutes (T4), and the pulmonary shunt fraction (Qs/Qt) was calculated. Results In group A, the PaO2 was obviously lower at T3 and T4 than at T1 (P<0.05, P<0.01), and there was no significant difference in pH, PaCO2, HCO3 and BE between the 4 time points. In group B, there was no significant difference of arterial blood gas values in 4 time points. The Qs/Qt value was obviously lower at T3 and T4 compared with that at T1 (P<0.01), and no significant difference in PAP, MAP, HR and SvO2 was found between the 4 time points in group A, while there was no significant difference in above indexes in 4 time points in group B. Conclusion The application of PEEP during solitary lung ventilation in open thoracic surgery may improve PaO2 and decrease pulmonary shunt fraction.DOI: 10.11855/j.issn.0577-7402.2013.12.08" @default.
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- W2238981562 date "2013-01-12" @default.
- W2238981562 modified "2023-09-24" @default.
- W2238981562 title "Effects of positive end-expiratory pressure on the oxygenation and shunt fraction during ventilation with solitary lung" @default.
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