Matches in SemOpenAlex for { <https://semopenalex.org/work/W22389945> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W22389945 abstract "6005 Background: We previously reported high rates of overall survival (OS) and laryngeal preservation in two sequential phase II trials with stage III/IV laryngeal squamous cell carcinoma patients (pts), who attained a >50% response after 1 cycle of induction chemotherapy, and who were treated with chemoradiation. Since then, all pts were re-staged to correspond with the most recent American Joint Committee on Cancer staging guidelines. Here we report the outcomes of the T 4 pts from both studies. Methods: Pts received 1 cycle of cisplatin 100 mg/m 2 & 5-FU 1,000 mg/m 2 /day × 5 days (P+5FU). Pts with > 50% response received chemoradiation with 70 Gy & P 100 mg/m 2 , days 1, 22, & 43. Pts with ≤ 50% response underwent laryngectomy. Final planned tumor assessment by direct laryngoscopy with biopsy was performed 8 wks after chemoradiation. Pts who were histologic complete responders, received 2 cycles of P+5FU. Pts with residual disease had planned salvage surgery. Results: Thirty-two T 4 eligible (cartilage invasion 31, base of tongue involvement 1) pts were enrolled, 23 M; 9 F; median age 56; stage: IVA 31, IVB 1; site: 19 supraglottic, 13 glottic. After 1 cycle induction chemotherapy, 26 pts (81%) had > 50% response & received chemoradiation; 5 (16%) had surgery; & 1 refused surgery. After chemoradiation, 22 pts had a complete histologic response, & 4 pts required immediate salvage larngectomy for residual disease. Of those responding to chemoradiation, 2 pts eventually required salvage laryngectomy. Currently, 17/32 (53%) are alive (15 without disease), 10 are dead of disease, & 5 are dead from other causes. Toxicity: grade 3/4 granulocytopenia 19%, grade 3/4 mucositis 49%. Median time to follow-up is 45 months. The 3 yr overall survival (OS) is 75% (95% CI=55%, 86%), & the 4 yr OS is 70% (95% CI = 50%, 83%). The 3 yr disease-free survival (DFS) is 77% (CI=58%, 88%), & the 4 yr DFS is 72% (CI=52%, 85%). Conclusions: Our results suggest that chemo-selection is an alternative, organ preservation strategy to total laryngectomy for pts with T 4 laryngeal squamous cell carcinoma. No significant financial relationships to disclose." @default.
- W22389945 created "2016-06-24" @default.
- W22389945 creator A5011529218 @default.
- W22389945 creator A5020538747 @default.
- W22389945 creator A5033670564 @default.
- W22389945 creator A5037094593 @default.
- W22389945 creator A5040159243 @default.
- W22389945 creator A5042170498 @default.
- W22389945 creator A5048011873 @default.
- W22389945 creator A5049286323 @default.
- W22389945 creator A5066404810 @default.
- W22389945 creator A5082980849 @default.
- W22389945 creator A5088306775 @default.
- W22389945 date "2007-06-20" @default.
- W22389945 modified "2023-09-23" @default.
- W22389945 title "Chemo-selection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma" @default.
- W22389945 doi "https://doi.org/10.1200/jco.2007.25.18_suppl.6005" @default.
- W22389945 hasPublicationYear "2007" @default.
- W22389945 type Work @default.
- W22389945 sameAs 22389945 @default.
- W22389945 citedByCount "2" @default.
- W22389945 countsByYear W223899452012 @default.
- W22389945 crossrefType "journal-article" @default.
- W22389945 hasAuthorship W22389945A5011529218 @default.
- W22389945 hasAuthorship W22389945A5020538747 @default.
- W22389945 hasAuthorship W22389945A5033670564 @default.
- W22389945 hasAuthorship W22389945A5037094593 @default.
- W22389945 hasAuthorship W22389945A5040159243 @default.
- W22389945 hasAuthorship W22389945A5042170498 @default.
- W22389945 hasAuthorship W22389945A5048011873 @default.
- W22389945 hasAuthorship W22389945A5049286323 @default.
- W22389945 hasAuthorship W22389945A5066404810 @default.
- W22389945 hasAuthorship W22389945A5082980849 @default.
- W22389945 hasAuthorship W22389945A5088306775 @default.
- W22389945 hasConcept C121608353 @default.
- W22389945 hasConcept C126322002 @default.
- W22389945 hasConcept C126894567 @default.
- W22389945 hasConcept C141071460 @default.
- W22389945 hasConcept C146357865 @default.
- W22389945 hasConcept C151730666 @default.
- W22389945 hasConcept C2775934546 @default.
- W22389945 hasConcept C2776611710 @default.
- W22389945 hasConcept C2776694085 @default.
- W22389945 hasConcept C2776888982 @default.
- W22389945 hasConcept C2778239845 @default.
- W22389945 hasConcept C2780474809 @default.
- W22389945 hasConcept C2781157581 @default.
- W22389945 hasConcept C3019992690 @default.
- W22389945 hasConcept C71924100 @default.
- W22389945 hasConcept C86803240 @default.
- W22389945 hasConceptScore W22389945C121608353 @default.
- W22389945 hasConceptScore W22389945C126322002 @default.
- W22389945 hasConceptScore W22389945C126894567 @default.
- W22389945 hasConceptScore W22389945C141071460 @default.
- W22389945 hasConceptScore W22389945C146357865 @default.
- W22389945 hasConceptScore W22389945C151730666 @default.
- W22389945 hasConceptScore W22389945C2775934546 @default.
- W22389945 hasConceptScore W22389945C2776611710 @default.
- W22389945 hasConceptScore W22389945C2776694085 @default.
- W22389945 hasConceptScore W22389945C2776888982 @default.
- W22389945 hasConceptScore W22389945C2778239845 @default.
- W22389945 hasConceptScore W22389945C2780474809 @default.
- W22389945 hasConceptScore W22389945C2781157581 @default.
- W22389945 hasConceptScore W22389945C3019992690 @default.
- W22389945 hasConceptScore W22389945C71924100 @default.
- W22389945 hasConceptScore W22389945C86803240 @default.
- W22389945 hasLocation W223899451 @default.
- W22389945 hasOpenAccess W22389945 @default.
- W22389945 hasPrimaryLocation W223899451 @default.
- W22389945 hasRelatedWork W2023463542 @default.
- W22389945 hasRelatedWork W2051094704 @default.
- W22389945 hasRelatedWork W2129226862 @default.
- W22389945 hasRelatedWork W2136595795 @default.
- W22389945 hasRelatedWork W2139450301 @default.
- W22389945 hasRelatedWork W2244730902 @default.
- W22389945 hasRelatedWork W2324071755 @default.
- W22389945 hasRelatedWork W2462005566 @default.
- W22389945 hasRelatedWork W2562414697 @default.
- W22389945 hasRelatedWork W2940901092 @default.
- W22389945 isParatext "false" @default.
- W22389945 isRetracted "false" @default.
- W22389945 magId "22389945" @default.
- W22389945 workType "article" @default.