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- W2239358663 abstract "The recently published overview of systemic treatment of patients with early breast cancer provides the best information available concerning the impact of these treatments on disease-free and overall survival [4] (reprinted in part in this volume). The modest reduction in risk of relapse achieved by these treatments may translate into major community health benefits when viewed in the context of a common disease affecting hundreds of thousands of women in the world each year. However, these results also indicate that many women who have received adjuvant systemic treatments die of metastatic breast cancer, presumably because some cells in the micrometastatic disease present before treatment survive after adjuvant treatment is ceased, and these cells later grow to cause advanced disease and premature death. Strategies to improve these results must include, on the one hand, the development of techniques to identify women with early breast cancer who have a normal life expectancy without adjuvant systemic therapy, i.e., either no metastases or metastases which will not cause symptoms during life, and, on the other, to establish the therapy which eliminates micrometastases or prevents their growth." @default.
- W2239358663 created "2016-06-24" @default.
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- W2239358663 date "1993-01-01" @default.
- W2239358663 modified "2023-10-18" @default.
- W2239358663 title "Mechanisms of Treatment Failure" @default.
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- W2239358663 doi "https://doi.org/10.1007/978-3-642-84745-5_6" @default.
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