Matches in SemOpenAlex for { <https://semopenalex.org/work/W2239523844> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2239523844 abstract "PR-1 The IGF-I axis has been proposed to be a significant factor in the development of certain cancers, including colorectal. However, results from epidemiological studies suggest modest effects on colorectal cancer risk. Using cross-sectional and prospective study designs within the same cohort, we investigated whether plasma IGF-I, IGFBP-1, and IGFBP-3 were associated with colorectal adenoma characteristics at baseline, and whether their levels were related to odds for adenoma recurrence. Plasma levels of each marker were measured at baseline in 299 male participants in the Wheat Bran Fiber Trial who were followed for recurrence of their adenomatous lesions. In cross-sectional analyses, plasma IGF-I was significantly positively associated with the presence of adenomas with any villous features (p=0.04). In contrast, IGF-I levels were inversely associated with odds of colorectal adenoma recurrence, with ORs (95% CIs) of 0.72 (0.37-1.38) and 0.52 (0.27-1.00) for the second and third tertiles of IGF-I, respectively, as compared to the first tertile (p-trend=0.05). The inverse association was stronger for advanced adenoma recurrence (p-trend=0.04) than for non-advanced recurrence (p-trend=0.16). These results suggest that while IGF-I may have adverse effects in existing premalignant lesions of the colorectum, individuals with elevated IGF-I levels are protected from the formation of new lesions in the colorectum." @default.
- W2239523844 created "2016-06-24" @default.
- W2239523844 creator A5015831837 @default.
- W2239523844 creator A5021761022 @default.
- W2239523844 creator A5023602308 @default.
- W2239523844 creator A5029541691 @default.
- W2239523844 creator A5035177417 @default.
- W2239523844 creator A5049898619 @default.
- W2239523844 creator A5078563084 @default.
- W2239523844 date "2007-12-01" @default.
- W2239523844 modified "2023-09-24" @default.
- W2239523844 title "Plasma IGF-I is inversely associated with colorectal adenoma recurrence" @default.
- W2239523844 hasPublicationYear "2007" @default.
- W2239523844 type Work @default.
- W2239523844 sameAs 2239523844 @default.
- W2239523844 citedByCount "0" @default.
- W2239523844 crossrefType "journal-article" @default.
- W2239523844 hasAuthorship W2239523844A5015831837 @default.
- W2239523844 hasAuthorship W2239523844A5021761022 @default.
- W2239523844 hasAuthorship W2239523844A5023602308 @default.
- W2239523844 hasAuthorship W2239523844A5029541691 @default.
- W2239523844 hasAuthorship W2239523844A5035177417 @default.
- W2239523844 hasAuthorship W2239523844A5049898619 @default.
- W2239523844 hasAuthorship W2239523844A5078563084 @default.
- W2239523844 hasConcept C107130276 @default.
- W2239523844 hasConcept C121608353 @default.
- W2239523844 hasConcept C126322002 @default.
- W2239523844 hasConcept C143998085 @default.
- W2239523844 hasConcept C156957248 @default.
- W2239523844 hasConcept C188816634 @default.
- W2239523844 hasConcept C2776861080 @default.
- W2239523844 hasConcept C2777428134 @default.
- W2239523844 hasConcept C2780914348 @default.
- W2239523844 hasConcept C50440223 @default.
- W2239523844 hasConcept C526805850 @default.
- W2239523844 hasConcept C71924100 @default.
- W2239523844 hasConcept C72563966 @default.
- W2239523844 hasConcept C90924648 @default.
- W2239523844 hasConceptScore W2239523844C107130276 @default.
- W2239523844 hasConceptScore W2239523844C121608353 @default.
- W2239523844 hasConceptScore W2239523844C126322002 @default.
- W2239523844 hasConceptScore W2239523844C143998085 @default.
- W2239523844 hasConceptScore W2239523844C156957248 @default.
- W2239523844 hasConceptScore W2239523844C188816634 @default.
- W2239523844 hasConceptScore W2239523844C2776861080 @default.
- W2239523844 hasConceptScore W2239523844C2777428134 @default.
- W2239523844 hasConceptScore W2239523844C2780914348 @default.
- W2239523844 hasConceptScore W2239523844C50440223 @default.
- W2239523844 hasConceptScore W2239523844C526805850 @default.
- W2239523844 hasConceptScore W2239523844C71924100 @default.
- W2239523844 hasConceptScore W2239523844C72563966 @default.
- W2239523844 hasConceptScore W2239523844C90924648 @default.
- W2239523844 hasLocation W22395238441 @default.
- W2239523844 hasOpenAccess W2239523844 @default.
- W2239523844 hasPrimaryLocation W22395238441 @default.
- W2239523844 hasRelatedWork W2007488022 @default.
- W2239523844 hasRelatedWork W2010491075 @default.
- W2239523844 hasRelatedWork W2013708901 @default.
- W2239523844 hasRelatedWork W2025927272 @default.
- W2239523844 hasRelatedWork W2065096639 @default.
- W2239523844 hasRelatedWork W2066289075 @default.
- W2239523844 hasRelatedWork W2078447501 @default.
- W2239523844 hasRelatedWork W2092172594 @default.
- W2239523844 hasRelatedWork W2099435960 @default.
- W2239523844 hasRelatedWork W2141163594 @default.
- W2239523844 hasRelatedWork W2147860823 @default.
- W2239523844 hasRelatedWork W2151646894 @default.
- W2239523844 hasRelatedWork W2161150757 @default.
- W2239523844 hasRelatedWork W2163972907 @default.
- W2239523844 hasRelatedWork W2164373820 @default.
- W2239523844 hasRelatedWork W2327992598 @default.
- W2239523844 hasRelatedWork W2331723635 @default.
- W2239523844 hasRelatedWork W2726610245 @default.
- W2239523844 hasRelatedWork W3018414744 @default.
- W2239523844 hasRelatedWork W3102091213 @default.
- W2239523844 hasVolume "16" @default.
- W2239523844 isParatext "false" @default.
- W2239523844 isRetracted "false" @default.
- W2239523844 magId "2239523844" @default.
- W2239523844 workType "article" @default.