FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2239961489> ?p ?o ?g. }

• W2239961489 endingPage "285" @default.
• W2239961489 startingPage "274" @default.
• W2239961489 abstract "A series of diseases, ranging from cholera via travelers' diarrhea to hamburger disease, are caused by bacterially produced toxic proteins. In particular, a toxic protein unit is brought into the host cell upon binding to specific membrane-bound oligosaccharides on the host cell membrane. For example, the protein that causes cholera, cholera toxin (CT), has five identical, symmetrically placed binding pockets (B proteins), on top of which the toxic A protein resides. A promising strategy to counteract the devastating biological effects of this AB5 protein involves the development of inhibitors that can act as mimics of membrane-bound GM1 molecules, i.e., that can bind CT strongly and selectively. To reach this goal, two features are essential: First of all, the inhibitor should display oligosaccharides that resemble as much as possible the naturally occurring cell-surface pentasaccharide onto which CT normally binds, the so-called GM1 sugar (the oligosaccharide part of which is then labeled GM1os). Second, the inhibitor should be able to bind CT via multivalent interactions so as to bind CT as strongly as possible to allow for a real competition with the cell-membrane-bound GM1 molecules. In this Account, we present elements of the path that leads to strong CT inhibition by outlining the roles of multivalency and the development and use of GM1 mimics. First, multivalency effects were investigated using sugar-coated platforms, ranging from dendritic structures with up to eight oligosaccharides to platforms that mimicked the fivefold symmetry of CT itself. The latter goal was reached either via synthetic scaffolds like corannulene or calix[5]arene or via the development of a neolectin CT mimic that itself carries five GM1os groups. Second, the effect of the nature of the oligosaccharide appended to this platform was investigated via the use of oligosaccharides of increasing complexity, from galactose and lactose to the tetrasaccharide GM2os and eventually to GM1os itself. The combination of these threads gives rise to a series of inhibitors that can strongly bind CT, with IC50 values below 100 pM, and in some cases can even bind one-on-one." @default.
• W2239961489 created "2016-06-24" @default.
• W2239961489 creator A5055120115 @default.
• W2239961489 date "2016-01-13" @default.
• W2239961489 modified "2023-10-08" @default.
• W2239961489 title "Fighting Cholera One-on-One: The Development and Efficacy of Multivalent Cholera-Toxin-Binding Molecules" @default.
• W2239961489 cites W1278164816 @default.
• W2239961489 cites W1661670649 @default.
• W2239961489 cites W1820499608 @default.
• W2239961489 cites W1843522855 @default.
• W2239961489 cites W1944106154 @default.
• W2239961489 cites W1966071060 @default.
• W2239961489 cites W1969703106 @default.
• W2239961489 cites W1979438209 @default.
• W2239961489 cites W1981154770 @default.
• W2239961489 cites W1996855722 @default.
• W2239961489 cites W2003312569 @default.
• W2239961489 cites W2003569888 @default.
• W2239961489 cites W2007990694 @default.
• W2239961489 cites W2019153426 @default.
• W2239961489 cites W2019274549 @default.
• W2239961489 cites W2020795580 @default.
• W2239961489 cites W2021566603 @default.
• W2239961489 cites W2024274577 @default.
• W2239961489 cites W2025493758 @default.
• W2239961489 cites W2026157780 @default.
• W2239961489 cites W2026703229 @default.
• W2239961489 cites W2028380020 @default.
• W2239961489 cites W2032377822 @default.
• W2239961489 cites W2036807411 @default.
• W2239961489 cites W2037061238 @default.
• W2239961489 cites W2038284222 @default.
• W2239961489 cites W2040778872 @default.
• W2239961489 cites W2045098870 @default.
• W2239961489 cites W2045902043 @default.
• W2239961489 cites W2052516870 @default.
• W2239961489 cites W2054072307 @default.
• W2239961489 cites W2067386986 @default.
• W2239961489 cites W2075917616 @default.
• W2239961489 cites W2084881844 @default.
• W2239961489 cites W2086739899 @default.
• W2239961489 cites W2096670802 @default.
• W2239961489 cites W2098548230 @default.
• W2239961489 cites W2101207743 @default.
• W2239961489 cites W2109971510 @default.
• W2239961489 cites W2117103203 @default.
• W2239961489 cites W2125428954 @default.
• W2239961489 cites W2141589632 @default.
• W2239961489 cites W2144086680 @default.
• W2239961489 cites W2146634463 @default.
• W2239961489 cites W2163449711 @default.
• W2239961489 cites W2166133779 @default.
• W2239961489 cites W2166474894 @default.
• W2239961489 cites W2167381087 @default.
• W2239961489 cites W2328607388 @default.
• W2239961489 cites W2331213730 @default.
• W2239961489 cites W2950591436 @default.
• W2239961489 cites W4210694483 @default.
• W2239961489 cites W4243919487 @default.
• W2239961489 doi "https://doi.org/10.1021/acs.accounts.5b00480" @default.
• W2239961489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26760438" @default.
• W2239961489 hasPublicationYear "2016" @default.
• W2239961489 type Work @default.
• W2239961489 sameAs 2239961489 @default.
• W2239961489 citedByCount "28" @default.
• W2239961489 countsByYear W22399614892016 @default.
• W2239961489 countsByYear W22399614892017 @default.
• W2239961489 countsByYear W22399614892018 @default.
• W2239961489 countsByYear W22399614892019 @default.
• W2239961489 countsByYear W22399614892020 @default.
• W2239961489 countsByYear W22399614892021 @default.
• W2239961489 countsByYear W22399614892022 @default.
• W2239961489 countsByYear W22399614892023 @default.
• W2239961489 crossrefType "journal-article" @default.
• W2239961489 hasAuthorship W2239961489A5055120115 @default.
• W2239961489 hasBestOaLocation W22399614891 @default.
• W2239961489 hasConcept C107824862 @default.
• W2239961489 hasConcept C12554922 @default.
• W2239961489 hasConcept C1491633281 @default.
• W2239961489 hasConcept C161624437 @default.
• W2239961489 hasConcept C185592680 @default.
• W2239961489 hasConcept C2777006276 @default.
• W2239961489 hasConcept C2778106830 @default.
• W2239961489 hasConcept C2778643871 @default.
• W2239961489 hasConcept C2780722889 @default.
• W2239961489 hasConcept C41625074 @default.
• W2239961489 hasConcept C523546767 @default.
• W2239961489 hasConcept C54355233 @default.
• W2239961489 hasConcept C55493867 @default.
• W2239961489 hasConcept C86803240 @default.
• W2239961489 hasConcept C89423630 @default.
• W2239961489 hasConcept C95444343 @default.
• W2239961489 hasConceptScore W2239961489C107824862 @default.
• W2239961489 hasConceptScore W2239961489C12554922 @default.
• W2239961489 hasConceptScore W2239961489C1491633281 @default.
• W2239961489 hasConceptScore W2239961489C161624437 @default.
• W2239961489 hasConceptScore W2239961489C185592680 @default.
• W2239961489 hasConceptScore W2239961489C2777006276 @default.

• next