FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2239986944> ?p ?o ?g. }

• W2239986944 endingPage "80" @default.
• W2239986944 startingPage "74" @default.
• W2239986944 abstract "Sulforaphane (SFN), an isothiocyanate isolated from broccoli, has been reported to have chemopreventive activity. However, the effects of SFN on lung cancer have not been investigated. In this study, we investigate the chemopreventive role of SFN through the inhibition of histone deacetylase (HDAC) in two different lung cancer cells by in vitro and in vivo mouse models. A549 and H1299 lung cancer cells were treated with SFN for 48 h. The HDAC activity, expression of acetylated histones H3 and H4, apoptosis and cell cycles were analyzed by western blot, qRT-PCR and flow cytometry. A549 cells were implanted into the immunocompromised mice for xenografts. The results showed that SFN inhibited HDAC activity and increased the levels of acetylated histones H3 and H4 in all two lung cancer cells. Further, SFN induced apoptosis, increased the accumulation of cells at G0/G1 and G2/M and arrest cells at S phase. We also found that a concomitant increase of apoptosis related proteins by SFN administration. More interestingly, SFN suppressed the lung cancer growth in xenograft mouse model. In conclusion, the chemopreventive effect of SFN is associated with inhibition of HDAC activity, thereby attenuating lung cancer growth. Therefore, these findings suggest that SFN may be a therapeutic agent for lung cancer through the inhibition of HDAC." @default.
• W2239986944 created "2016-06-24" @default.
• W2239986944 creator A5017676873 @default.
• W2239986944 creator A5018390407 @default.
• W2239986944 creator A5024016708 @default.
• W2239986944 creator A5071037763 @default.
• W2239986944 creator A5071155203 @default.
• W2239986944 date "2016-03-01" @default.
• W2239986944 modified "2023-09-26" @default.
• W2239986944 title "Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity" @default.
• W2239986944 cites W1585911052 @default.
• W2239986944 cites W1852761976 @default.
• W2239986944 cites W1967018540 @default.
• W2239986944 cites W1967077010 @default.
• W2239986944 cites W1977004529 @default.
• W2239986944 cites W1985264467 @default.
• W2239986944 cites W2011660168 @default.
• W2239986944 cites W2025041464 @default.
• W2239986944 cites W2025054234 @default.
• W2239986944 cites W2029933341 @default.
• W2239986944 cites W2049714385 @default.
• W2239986944 cites W2051026285 @default.
• W2239986944 cites W2052884996 @default.
• W2239986944 cites W2053821985 @default.
• W2239986944 cites W2069872683 @default.
• W2239986944 cites W2071383329 @default.
• W2239986944 cites W2074300509 @default.
• W2239986944 cites W2084996794 @default.
• W2239986944 cites W2096035514 @default.
• W2239986944 cites W2118287650 @default.
• W2239986944 cites W2121296685 @default.
• W2239986944 cites W2124569198 @default.
• W2239986944 cites W2134669826 @default.
• W2239986944 cites W2136881121 @default.
• W2239986944 cites W2147036069 @default.
• W2239986944 cites W2154384337 @default.
• W2239986944 cites W2156559492 @default.
• W2239986944 cites W2157607726 @default.
• W2239986944 cites W2158971210 @default.
• W2239986944 cites W2161817637 @default.
• W2239986944 doi "https://doi.org/10.1016/j.biopha.2015.11.007" @default.
• W2239986944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26898427" @default.
• W2239986944 hasPublicationYear "2016" @default.
• W2239986944 type Work @default.
• W2239986944 sameAs 2239986944 @default.
• W2239986944 citedByCount "54" @default.
• W2239986944 countsByYear W22399869442016 @default.
• W2239986944 countsByYear W22399869442017 @default.
• W2239986944 countsByYear W22399869442018 @default.
• W2239986944 countsByYear W22399869442019 @default.
• W2239986944 countsByYear W22399869442020 @default.
• W2239986944 countsByYear W22399869442021 @default.
• W2239986944 countsByYear W22399869442022 @default.
• W2239986944 countsByYear W22399869442023 @default.
• W2239986944 crossrefType "journal-article" @default.
• W2239986944 hasAuthorship W2239986944A5017676873 @default.
• W2239986944 hasAuthorship W2239986944A5018390407 @default.
• W2239986944 hasAuthorship W2239986944A5024016708 @default.
• W2239986944 hasAuthorship W2239986944A5071037763 @default.
• W2239986944 hasAuthorship W2239986944A5071155203 @default.
• W2239986944 hasConcept C104317684 @default.
• W2239986944 hasConcept C121608353 @default.
• W2239986944 hasConcept C126322002 @default.
• W2239986944 hasConcept C127561419 @default.
• W2239986944 hasConcept C150903083 @default.
• W2239986944 hasConcept C185592680 @default.
• W2239986944 hasConcept C190283241 @default.
• W2239986944 hasConcept C202751555 @default.
• W2239986944 hasConcept C207001950 @default.
• W2239986944 hasConcept C2776256026 @default.
• W2239986944 hasConcept C2776572452 @default.
• W2239986944 hasConcept C2778305200 @default.
• W2239986944 hasConcept C2779707156 @default.
• W2239986944 hasConcept C2780740852 @default.
• W2239986944 hasConcept C2780841255 @default.
• W2239986944 hasConcept C29537977 @default.
• W2239986944 hasConcept C502942594 @default.
• W2239986944 hasConcept C55493867 @default.
• W2239986944 hasConcept C555283112 @default.
• W2239986944 hasConcept C62112901 @default.
• W2239986944 hasConcept C64927066 @default.
• W2239986944 hasConcept C71924100 @default.
• W2239986944 hasConcept C81729549 @default.
• W2239986944 hasConcept C86803240 @default.
• W2239986944 hasConceptScore W2239986944C104317684 @default.
• W2239986944 hasConceptScore W2239986944C121608353 @default.
• W2239986944 hasConceptScore W2239986944C126322002 @default.
• W2239986944 hasConceptScore W2239986944C127561419 @default.
• W2239986944 hasConceptScore W2239986944C150903083 @default.
• W2239986944 hasConceptScore W2239986944C185592680 @default.
• W2239986944 hasConceptScore W2239986944C190283241 @default.
• W2239986944 hasConceptScore W2239986944C202751555 @default.
• W2239986944 hasConceptScore W2239986944C207001950 @default.
• W2239986944 hasConceptScore W2239986944C2776256026 @default.
• W2239986944 hasConceptScore W2239986944C2776572452 @default.
• W2239986944 hasConceptScore W2239986944C2778305200 @default.
• W2239986944 hasConceptScore W2239986944C2779707156 @default.
• W2239986944 hasConceptScore W2239986944C2780740852 @default.

• next