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- W224002922 abstract "Abstract : The ultimate objective was to develop physicochemically and biologically relevant algorithms with which the rate and extent of absorption of a chemical following derma contact can be accurately predicted for diverse exposure scenarios. The rational for the proposed approach is based on the fact that manifestations of toxicity (local and/or systemic) following cutaneous exposure requires the transdermal penetration of the chemical. The unique permeation barrier properties of skin ensure that the kinetics of percutaneous absorption will determine the severity and time-course of any potential hazard. The long-term objective of meaningful risk assessment following dermal exposure, therefore, requires that the rate of skin penetration in man be predictable. The specific aims of the project were: (1) to derive, from a comprehensive database of the percutaneous absorption/penetration literature predictive (structure-activity) algorithms to calculate a chemical's steady-state permeability (and constitutive diffusion and partition coefficients) across the skin. (2) To test the predictions of the unsteady-state modeling in vivo in humans using novel noninvasive methodology (accelerator mass spectrometry and attenuated total reflectance infrared spectroscopy)." @default.
- W224002922 created "2016-06-24" @default.
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- W224002922 date "1998-08-31" @default.
- W224002922 modified "2023-10-14" @default.
- W224002922 title "Prediction & Assessment of Dermal Exposure" @default.
- W224002922 doi "https://doi.org/10.21236/ada358903" @default.
- W224002922 hasPublicationYear "1998" @default.
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