Matches in SemOpenAlex for { <https://semopenalex.org/work/W2240360006> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2240360006 abstract "Background and Objectives: An elevated white blood cell (WBC) count has been reported to be associated with all-cause mortality and risk of cardiovascular diseases. While the relationship between leukocyte count and coronary heart disease has been well documented, evidence on the association with risk of stroke has been less consistent. The aim of this study was to investigate the relationship between WBC count and incidence of stroke in a large cohort of disease-free men and women, and to assess how far any associations might be explained by traditional risk factors for stroke. Methods: We examined the prospective association between full blood WBC count and incident stroke in 7,392 men and 9,049 women from the general population participating in the European Prospective Investigation into Cancer-Norfolk Study. Participants were aged 39-79 years, without known heart attack, stroke, and cancer at the baseline examination in 1993-1997 and were followed up for incident stroke till March 2008. Results: During the median follow-up of 12 years, 542 incident stroke cases were observed. The age- and sex- adjusted risk of incident stroke increased with the increase of WBC count. Compared to the lowest quartile of WBC count, the age- and sex- adjusted hazard ratios (HRs) and 95% CIs for stroke were 1.11 (0.86-1.45), 1.40 (1.10-1.79), and 1.65 (1.29-2.09) in the second, third, and fourth quartile, respectively. Adjusting for smoking attenuated the results, while further adjustment for socioeconomic and lifestyle risk factors changed the association very little. The association was further attenuated after adjustment for biological risk factors such as systolic blood pressure and a history of diabetes at baseline, but people with the highest quartile of WBC count still had a higher risk of stroke than those in the lowest quartile (HR 1.32, 95% CI 1.02-1.71). Every 2*10 9 /L increase in WBC count was associated with a hazard ratio of 1.14 (95% CI 1.02-1.26) for stroke in the fully-adjusted model which included age, sex, smoking status, BMI, social class, educational level, alcohol intake, physical activity, systolic blood pressure, a history of diabetes at baseline, and total serum cholesterol. Conclusions: A positive association between WBC count and stroke was observed in these middle-aged and older men and women. Adjustment for smoking attenuated the association while multivariate adjustment for other risk factors did not further change the results." @default.
- W2240360006 created "2016-06-24" @default.
- W2240360006 creator A5040307802 @default.
- W2240360006 creator A5047931301 @default.
- W2240360006 creator A5057904076 @default.
- W2240360006 creator A5064731399 @default.
- W2240360006 creator A5064980874 @default.
- W2240360006 creator A5083082581 @default.
- W2240360006 date "2012-02-01" @default.
- W2240360006 modified "2023-10-16" @default.
- W2240360006 title "Abstract 146: White Blood Cell Count and Risk of Stroke in Men and Women: the European Prospective Investigation into Cancer-Norfolk Prospective Population Study" @default.
- W2240360006 doi "https://doi.org/10.1161/str.43.suppl_1.a146" @default.
- W2240360006 hasPublicationYear "2012" @default.
- W2240360006 type Work @default.
- W2240360006 sameAs 2240360006 @default.
- W2240360006 citedByCount "0" @default.
- W2240360006 crossrefType "journal-article" @default.
- W2240360006 hasAuthorship W2240360006A5040307802 @default.
- W2240360006 hasAuthorship W2240360006A5047931301 @default.
- W2240360006 hasAuthorship W2240360006A5057904076 @default.
- W2240360006 hasAuthorship W2240360006A5064731399 @default.
- W2240360006 hasAuthorship W2240360006A5064980874 @default.
- W2240360006 hasAuthorship W2240360006A5083082581 @default.
- W2240360006 hasConcept C120665830 @default.
- W2240360006 hasConcept C121332964 @default.
- W2240360006 hasConcept C126322002 @default.
- W2240360006 hasConcept C127413603 @default.
- W2240360006 hasConcept C188816634 @default.
- W2240360006 hasConcept C201903717 @default.
- W2240360006 hasConcept C207103383 @default.
- W2240360006 hasConcept C2780645631 @default.
- W2240360006 hasConcept C2908647359 @default.
- W2240360006 hasConcept C44249647 @default.
- W2240360006 hasConcept C50382708 @default.
- W2240360006 hasConcept C61511704 @default.
- W2240360006 hasConcept C68443243 @default.
- W2240360006 hasConcept C71924100 @default.
- W2240360006 hasConcept C78519656 @default.
- W2240360006 hasConcept C99454951 @default.
- W2240360006 hasConceptScore W2240360006C120665830 @default.
- W2240360006 hasConceptScore W2240360006C121332964 @default.
- W2240360006 hasConceptScore W2240360006C126322002 @default.
- W2240360006 hasConceptScore W2240360006C127413603 @default.
- W2240360006 hasConceptScore W2240360006C188816634 @default.
- W2240360006 hasConceptScore W2240360006C201903717 @default.
- W2240360006 hasConceptScore W2240360006C207103383 @default.
- W2240360006 hasConceptScore W2240360006C2780645631 @default.
- W2240360006 hasConceptScore W2240360006C2908647359 @default.
- W2240360006 hasConceptScore W2240360006C44249647 @default.
- W2240360006 hasConceptScore W2240360006C50382708 @default.
- W2240360006 hasConceptScore W2240360006C61511704 @default.
- W2240360006 hasConceptScore W2240360006C68443243 @default.
- W2240360006 hasConceptScore W2240360006C71924100 @default.
- W2240360006 hasConceptScore W2240360006C78519656 @default.
- W2240360006 hasConceptScore W2240360006C99454951 @default.
- W2240360006 hasIssue "suppl_1" @default.
- W2240360006 hasLocation W22403600061 @default.
- W2240360006 hasOpenAccess W2240360006 @default.
- W2240360006 hasPrimaryLocation W22403600061 @default.
- W2240360006 hasRelatedWork W1625399553 @default.
- W2240360006 hasRelatedWork W1967565084 @default.
- W2240360006 hasRelatedWork W1980465234 @default.
- W2240360006 hasRelatedWork W2016015917 @default.
- W2240360006 hasRelatedWork W2042567816 @default.
- W2240360006 hasRelatedWork W2074203408 @default.
- W2240360006 hasRelatedWork W2103554584 @default.
- W2240360006 hasRelatedWork W2142777930 @default.
- W2240360006 hasRelatedWork W2165541360 @default.
- W2240360006 hasRelatedWork W2346107837 @default.
- W2240360006 hasRelatedWork W2418510071 @default.
- W2240360006 hasRelatedWork W2469783431 @default.
- W2240360006 hasRelatedWork W2599592635 @default.
- W2240360006 hasRelatedWork W2897225584 @default.
- W2240360006 hasRelatedWork W2974871484 @default.
- W2240360006 hasRelatedWork W3128765597 @default.
- W2240360006 hasRelatedWork W3142482271 @default.
- W2240360006 hasRelatedWork W3150863207 @default.
- W2240360006 hasRelatedWork W3209738690 @default.
- W2240360006 hasRelatedWork W3213285908 @default.
- W2240360006 hasVolume "43" @default.
- W2240360006 isParatext "false" @default.
- W2240360006 isRetracted "false" @default.
- W2240360006 magId "2240360006" @default.
- W2240360006 workType "article" @default.