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- W2240417434 abstract "15579 Background: Meaningful survival for patients with pancreatic cancer requires surgical resection; adjuvant therapy has been demonstrated to improve survival. However, actual rates of resection and adjuvant therapy for patients referred for surgical resection remain unknown. Methods: This study examined 104 consecutive patients with pancreatic adenocarcinoma evaluated at a single surgical center from January 1, 2002- June 30, 2007. Patients were identified from a prospective pancreatic database; medical records were retrospectively reviewed. Results: Of 104 referred patients, 32 were found on further preoperative workup to have locally advanced or metastatic disease; 9 patients who had apparently resectable tumors did not undergo operation because of poor performance status (6) or patient preference (3). 63 patients were taken to the operating room with curative intent, of whom 8 were found to have metastasis and 3 were found to have locally advanced disease upon surgical exploration. 52 patients underwent resection with curative intent, of whom 30 completed adjuvant therapy, defined as radiation and systemic chemotherapy (23) or neoadjuvant therapy followed by resection (7). Reasons for not completing adjuvant therapy included surgical (6) or medical (2) complications; disease progression (3); and patient preference (2); 9 patients had adjuvant therapy planned but not completed at the time of these analyses. Conclusions: Of the 104 patients referred for possible resection of pancreatic cancer, 60.6% (63/104) underwent attempted curative operation, and 50.0% (52/104) had successful pancreatic resection. Of those undergoing resection, 57.7% (30/52) completed adjuvant/neoadjuvant chemoradiation. Our results suggest that a substantial proportion of patients with apparently resectable pancreatic cancer do not complete the recommended surgery and adjuvant therapy in a timely fashion. Given the lack of recent progress demonstrated in clinical trials of novel pancreatic cancer therapies, increasing the proportion of patients who receive all indicated components of treatment, including surgical resection and adjuvant therapy, may currently be among the best methods of improving overall survival for patients with pancreatic adenocarcinoma. No significant financial relationships to disclose." @default.
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- W2240417434 date "2008-05-20" @default.
- W2240417434 modified "2023-10-14" @default.
- W2240417434 title "Do patients with apparently resectable pancreatic adenocarcinoma receive guideline-directed care?" @default.
- W2240417434 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.15579" @default.
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