Matches in SemOpenAlex for { <https://semopenalex.org/work/W2240446002> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2240446002 abstract "Prenatal exposure to high levels of glucocorticoids (GCs) predisposes to hypertension in later life. GCs regulate catecholamine biosynthesis and are critical for blood pressure homeostasis. This study examined whether prenatal exposure to elevated GCs influences the development of adult hypertension via alterations in phenylethanolamine N-methyl transferase (PNMT), a gene that is linked to hypertension. Pregnant Wistar-Kyoto dams were injected with 100 μg/kg/day of the synthetic GC dexamethasone (DEX) in their third trimester. Blood pressure and weights of the offspring were measured from week 3-18, at which point the animals were sacrificed. Total RNA and protein were extracted from the adrenals, and the expression of PNMT and its regulatory transcription factors analyzed by qPCR and Western blot. Results reveal that in utero exposure to DEX promotes the development of hypertension in the offspring. A more pronounced increase in blood pressure was seen in males than females. The mRNA transcripts for PNMT, and its transcriptional regulators Egr-1, Sp1, GR and AP-2, were elevated in the adrenals of these animals compared to saline controls, with differences in both sexes. Preliminary Western data also shows upregulation of PNMT and the transcription factor Egr-1. These results suggest that prenatal GC exposure increases adrenal PNMT gene expression via altered transcriptional regulatory mechanisms. Grant Funding Source: Supported by CIHR" @default.
- W2240446002 created "2016-06-24" @default.
- W2240446002 creator A5005971332 @default.
- W2240446002 creator A5017859552 @default.
- W2240446002 creator A5030032266 @default.
- W2240446002 creator A5032255165 @default.
- W2240446002 creator A5063569019 @default.
- W2240446002 creator A5075618672 @default.
- W2240446002 creator A5083582869 @default.
- W2240446002 date "2014-04-01" @default.
- W2240446002 modified "2023-10-01" @default.
- W2240446002 title "Sex differences in the fetal programming of hypertension: role of adrenal phenylethanolamine N‐methyltransferase gene expression (680.21)" @default.
- W2240446002 doi "https://doi.org/10.1096/fasebj.28.1_supplement.680.21" @default.
- W2240446002 hasPublicationYear "2014" @default.
- W2240446002 type Work @default.
- W2240446002 sameAs 2240446002 @default.
- W2240446002 citedByCount "0" @default.
- W2240446002 crossrefType "journal-article" @default.
- W2240446002 hasAuthorship W2240446002A5005971332 @default.
- W2240446002 hasAuthorship W2240446002A5017859552 @default.
- W2240446002 hasAuthorship W2240446002A5030032266 @default.
- W2240446002 hasAuthorship W2240446002A5032255165 @default.
- W2240446002 hasAuthorship W2240446002A5063569019 @default.
- W2240446002 hasAuthorship W2240446002A5075618672 @default.
- W2240446002 hasAuthorship W2240446002A5083582869 @default.
- W2240446002 hasConcept C104317684 @default.
- W2240446002 hasConcept C112672928 @default.
- W2240446002 hasConcept C126322002 @default.
- W2240446002 hasConcept C127561419 @default.
- W2240446002 hasConcept C134018914 @default.
- W2240446002 hasConcept C150194340 @default.
- W2240446002 hasConcept C159167319 @default.
- W2240446002 hasConcept C172680121 @default.
- W2240446002 hasConcept C2776804559 @default.
- W2240446002 hasConcept C2779234561 @default.
- W2240446002 hasConcept C2779546955 @default.
- W2240446002 hasConcept C2780401358 @default.
- W2240446002 hasConcept C513476851 @default.
- W2240446002 hasConcept C54355233 @default.
- W2240446002 hasConcept C71924100 @default.
- W2240446002 hasConcept C84393581 @default.
- W2240446002 hasConcept C86803240 @default.
- W2240446002 hasConceptScore W2240446002C104317684 @default.
- W2240446002 hasConceptScore W2240446002C112672928 @default.
- W2240446002 hasConceptScore W2240446002C126322002 @default.
- W2240446002 hasConceptScore W2240446002C127561419 @default.
- W2240446002 hasConceptScore W2240446002C134018914 @default.
- W2240446002 hasConceptScore W2240446002C150194340 @default.
- W2240446002 hasConceptScore W2240446002C159167319 @default.
- W2240446002 hasConceptScore W2240446002C172680121 @default.
- W2240446002 hasConceptScore W2240446002C2776804559 @default.
- W2240446002 hasConceptScore W2240446002C2779234561 @default.
- W2240446002 hasConceptScore W2240446002C2779546955 @default.
- W2240446002 hasConceptScore W2240446002C2780401358 @default.
- W2240446002 hasConceptScore W2240446002C513476851 @default.
- W2240446002 hasConceptScore W2240446002C54355233 @default.
- W2240446002 hasConceptScore W2240446002C71924100 @default.
- W2240446002 hasConceptScore W2240446002C84393581 @default.
- W2240446002 hasConceptScore W2240446002C86803240 @default.
- W2240446002 hasFunder F4320334506 @default.
- W2240446002 hasIssue "S1" @default.
- W2240446002 hasLocation W22404460021 @default.
- W2240446002 hasOpenAccess W2240446002 @default.
- W2240446002 hasPrimaryLocation W22404460021 @default.
- W2240446002 hasRelatedWork W1512831350 @default.
- W2240446002 hasRelatedWork W1962700934 @default.
- W2240446002 hasRelatedWork W1974684692 @default.
- W2240446002 hasRelatedWork W1981364394 @default.
- W2240446002 hasRelatedWork W2039107040 @default.
- W2240446002 hasRelatedWork W2062252989 @default.
- W2240446002 hasRelatedWork W2074314021 @default.
- W2240446002 hasRelatedWork W2082175210 @default.
- W2240446002 hasRelatedWork W2117080819 @default.
- W2240446002 hasRelatedWork W4234517484 @default.
- W2240446002 hasVolume "28" @default.
- W2240446002 isParatext "false" @default.
- W2240446002 isRetracted "false" @default.
- W2240446002 magId "2240446002" @default.
- W2240446002 workType "article" @default.