Matches in SemOpenAlex for { <https://semopenalex.org/work/W2240765188> ?p ?o ?g. }
- W2240765188 endingPage "477" @default.
- W2240765188 startingPage "469" @default.
- W2240765188 abstract "Abstract Hypoxia-inducible factor–2α (HIF-2α) is highly expressed in embryonic vascular endothelial cells (ECs) and activates the expression of target genes whose products modulate vascular function and angiogenesis. In this report, we describe a genetic model designed to test the physiologic consequences of deleting HIF-2α in murine endothelial cells. Surprisingly, mice with HIF-2α–deficient ECs developed normally but displayed a variety of phenotypes, including increased vessel permeability, aberrant endothelial cell ultrastructure, and pulmonary hypertension. Moreover, these animals exhibited defective tumor angiogenesis associated with increased hypoxic stress and tumor cell apoptosis. Immortalized HIF-2α–deficient ECs displayed decreased adhesion to extracellular matrix proteins and expressed reduced levels of transcripts encoding fibronectin, integrins, endothelin B receptor, angiopoietin 2, and delta-like ligand 4 (Dll4). Together, these data identify unique cell-autonomous functions for HIF-2α in vascular endothelial cells." @default.
- W2240765188 created "2016-06-24" @default.
- W2240765188 creator A5007317144 @default.
- W2240765188 creator A5021809579 @default.
- W2240765188 creator A5027322124 @default.
- W2240765188 creator A5041810957 @default.
- W2240765188 creator A5042689320 @default.
- W2240765188 creator A5047702016 @default.
- W2240765188 creator A5056696028 @default.
- W2240765188 creator A5069659059 @default.
- W2240765188 creator A5089488756 @default.
- W2240765188 date "2009-07-09" @default.
- W2240765188 modified "2023-10-10" @default.
- W2240765188 title "Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis" @default.
- W2240765188 cites W1480357432 @default.
- W2240765188 cites W1597321356 @default.
- W2240765188 cites W1967194906 @default.
- W2240765188 cites W1967251768 @default.
- W2240765188 cites W1968085750 @default.
- W2240765188 cites W1973333497 @default.
- W2240765188 cites W1977927764 @default.
- W2240765188 cites W1987662957 @default.
- W2240765188 cites W1990110300 @default.
- W2240765188 cites W1990607537 @default.
- W2240765188 cites W1991346678 @default.
- W2240765188 cites W1997422780 @default.
- W2240765188 cites W1998287845 @default.
- W2240765188 cites W2014077602 @default.
- W2240765188 cites W2016805904 @default.
- W2240765188 cites W2017846490 @default.
- W2240765188 cites W2021656373 @default.
- W2240765188 cites W2023148812 @default.
- W2240765188 cites W2024131284 @default.
- W2240765188 cites W2024564719 @default.
- W2240765188 cites W2030319693 @default.
- W2240765188 cites W2044204971 @default.
- W2240765188 cites W2044257922 @default.
- W2240765188 cites W2050397881 @default.
- W2240765188 cites W2051531582 @default.
- W2240765188 cites W2054848045 @default.
- W2240765188 cites W2060525294 @default.
- W2240765188 cites W2064489090 @default.
- W2240765188 cites W2075773133 @default.
- W2240765188 cites W2092373300 @default.
- W2240765188 cites W2095528497 @default.
- W2240765188 cites W2101084498 @default.
- W2240765188 cites W2103464580 @default.
- W2240765188 cites W2105925116 @default.
- W2240765188 cites W2108186386 @default.
- W2240765188 cites W2112337731 @default.
- W2240765188 cites W2117779825 @default.
- W2240765188 cites W2120657231 @default.
- W2240765188 cites W2121744013 @default.
- W2240765188 cites W2122535638 @default.
- W2240765188 cites W2124053736 @default.
- W2240765188 cites W2125039061 @default.
- W2240765188 cites W2136023563 @default.
- W2240765188 cites W2136875815 @default.
- W2240765188 cites W2144026946 @default.
- W2240765188 cites W2147071344 @default.
- W2240765188 cites W2153726848 @default.
- W2240765188 cites W2168026099 @default.
- W2240765188 cites W2170415773 @default.
- W2240765188 doi "https://doi.org/10.1182/blood-2008-12-193581" @default.
- W2240765188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2714217" @default.
- W2240765188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19439736" @default.
- W2240765188 hasPublicationYear "2009" @default.
- W2240765188 type Work @default.
- W2240765188 sameAs 2240765188 @default.
- W2240765188 citedByCount "209" @default.
- W2240765188 countsByYear W22407651882012 @default.
- W2240765188 countsByYear W22407651882013 @default.
- W2240765188 countsByYear W22407651882014 @default.
- W2240765188 countsByYear W22407651882015 @default.
- W2240765188 countsByYear W22407651882016 @default.
- W2240765188 countsByYear W22407651882017 @default.
- W2240765188 countsByYear W22407651882018 @default.
- W2240765188 countsByYear W22407651882019 @default.
- W2240765188 countsByYear W22407651882020 @default.
- W2240765188 countsByYear W22407651882021 @default.
- W2240765188 countsByYear W22407651882022 @default.
- W2240765188 countsByYear W22407651882023 @default.
- W2240765188 crossrefType "journal-article" @default.
- W2240765188 hasAuthorship W2240765188A5007317144 @default.
- W2240765188 hasAuthorship W2240765188A5021809579 @default.
- W2240765188 hasAuthorship W2240765188A5027322124 @default.
- W2240765188 hasAuthorship W2240765188A5041810957 @default.
- W2240765188 hasAuthorship W2240765188A5042689320 @default.
- W2240765188 hasAuthorship W2240765188A5047702016 @default.
- W2240765188 hasAuthorship W2240765188A5056696028 @default.
- W2240765188 hasAuthorship W2240765188A5069659059 @default.
- W2240765188 hasAuthorship W2240765188A5089488756 @default.
- W2240765188 hasBestOaLocation W22407651881 @default.
- W2240765188 hasConcept C103041312 @default.
- W2240765188 hasConcept C113045295 @default.
- W2240765188 hasConcept C123012128 @default.
- W2240765188 hasConcept C134018914 @default.
- W2240765188 hasConcept C146285616 @default.