Matches in SemOpenAlex for { <https://semopenalex.org/work/W2240862704> ?p ?o ?g. }
- W2240862704 endingPage "e0142800" @default.
- W2240862704 startingPage "e0142800" @default.
- W2240862704 abstract "Leishmania donovani, a protozoan parasite, causes the disease visceral leishmanisis (VL), characterized by inappropriate CD8+ T-cell activation. Therefore, we examined whether the Toll-like Receptor 2 (TLR2) ligand Ara-LAM, a cell wall glycolipid from non-pathogenic Mycobacterium smegmatis, would restore CD8+ T-cell function during VL. We observed that by efficient upregulation of TLR2 signaling-mediated NF-κB translocation and MAPK signaling in CD8+ T-cells (CD25+CD28+IL-12R+IFN-γR+), Ara-LAM triggered signaling resulted in the activation of T-bet, which in turn, induced transcription favourable histone modification at the IFN-γ, perforin, granzyme-B promoter regions in CD8+ T-cells. Thus, we conclude that Ara-LAM induced efficient activation of effector CD8+ T-cells by upregulating the expression of IFN-γ, perforin and granzyme-B in an NF-κB and MAPK induced T-bet dependent manner in VL." @default.
- W2240862704 created "2016-06-24" @default.
- W2240862704 creator A5006550633 @default.
- W2240862704 creator A5007896564 @default.
- W2240862704 creator A5012008910 @default.
- W2240862704 creator A5024742527 @default.
- W2240862704 creator A5028351897 @default.
- W2240862704 creator A5030976720 @default.
- W2240862704 creator A5041004304 @default.
- W2240862704 creator A5064025120 @default.
- W2240862704 creator A5071866294 @default.
- W2240862704 date "2015-11-11" @default.
- W2240862704 modified "2023-10-14" @default.
- W2240862704 title "Toll-Like Receptor 2 Targeted Rectification of Impaired CD8+ T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection" @default.
- W2240862704 cites W1532828658 @default.
- W2240862704 cites W1574046283 @default.
- W2240862704 cites W1601816956 @default.
- W2240862704 cites W1932511623 @default.
- W2240862704 cites W1972349011 @default.
- W2240862704 cites W1977939808 @default.
- W2240862704 cites W1979332019 @default.
- W2240862704 cites W1996671942 @default.
- W2240862704 cites W2008376562 @default.
- W2240862704 cites W2015823023 @default.
- W2240862704 cites W2018289835 @default.
- W2240862704 cites W2019993326 @default.
- W2240862704 cites W2021497037 @default.
- W2240862704 cites W2022607188 @default.
- W2240862704 cites W2024949498 @default.
- W2240862704 cites W2047627836 @default.
- W2240862704 cites W2061442098 @default.
- W2240862704 cites W2068592961 @default.
- W2240862704 cites W2071275789 @default.
- W2240862704 cites W2086101311 @default.
- W2240862704 cites W2098568749 @default.
- W2240862704 cites W2101108802 @default.
- W2240862704 cites W2101884986 @default.
- W2240862704 cites W2102500641 @default.
- W2240862704 cites W2102810679 @default.
- W2240862704 cites W2110768898 @default.
- W2240862704 cites W2115879295 @default.
- W2240862704 cites W2125038701 @default.
- W2240862704 cites W2129087217 @default.
- W2240862704 cites W2129514368 @default.
- W2240862704 cites W2143765931 @default.
- W2240862704 cites W2145121719 @default.
- W2240862704 cites W2164746509 @default.
- W2240862704 cites W2167017590 @default.
- W2240862704 cites W2169167513 @default.
- W2240862704 doi "https://doi.org/10.1371/journal.pone.0142800" @default.
- W2240862704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641719" @default.
- W2240862704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26559815" @default.
- W2240862704 hasPublicationYear "2015" @default.
- W2240862704 type Work @default.
- W2240862704 sameAs 2240862704 @default.
- W2240862704 citedByCount "6" @default.
- W2240862704 countsByYear W22408627042016 @default.
- W2240862704 countsByYear W22408627042017 @default.
- W2240862704 countsByYear W22408627042018 @default.
- W2240862704 countsByYear W22408627042019 @default.
- W2240862704 countsByYear W22408627042021 @default.
- W2240862704 countsByYear W22408627042022 @default.
- W2240862704 crossrefType "journal-article" @default.
- W2240862704 hasAuthorship W2240862704A5006550633 @default.
- W2240862704 hasAuthorship W2240862704A5007896564 @default.
- W2240862704 hasAuthorship W2240862704A5012008910 @default.
- W2240862704 hasAuthorship W2240862704A5024742527 @default.
- W2240862704 hasAuthorship W2240862704A5028351897 @default.
- W2240862704 hasAuthorship W2240862704A5030976720 @default.
- W2240862704 hasAuthorship W2240862704A5041004304 @default.
- W2240862704 hasAuthorship W2240862704A5064025120 @default.
- W2240862704 hasAuthorship W2240862704A5071866294 @default.
- W2240862704 hasBestOaLocation W22408627041 @default.
- W2240862704 hasConcept C136449434 @default.
- W2240862704 hasConcept C154317977 @default.
- W2240862704 hasConcept C167672396 @default.
- W2240862704 hasConcept C183193105 @default.
- W2240862704 hasConcept C202751555 @default.
- W2240862704 hasConcept C203014093 @default.
- W2240862704 hasConcept C2776062744 @default.
- W2240862704 hasConcept C2776070231 @default.
- W2240862704 hasConcept C2776090121 @default.
- W2240862704 hasConcept C2776555147 @default.
- W2240862704 hasConcept C2776709828 @default.
- W2240862704 hasConcept C2778689377 @default.
- W2240862704 hasConcept C2780380082 @default.
- W2240862704 hasConcept C2781101188 @default.
- W2240862704 hasConcept C2781236682 @default.
- W2240862704 hasConcept C2781333301 @default.
- W2240862704 hasConcept C55493867 @default.
- W2240862704 hasConcept C62478195 @default.
- W2240862704 hasConcept C79484868 @default.
- W2240862704 hasConcept C86803240 @default.
- W2240862704 hasConcept C8891405 @default.
- W2240862704 hasConcept C95444343 @default.
- W2240862704 hasConceptScore W2240862704C136449434 @default.
- W2240862704 hasConceptScore W2240862704C154317977 @default.
- W2240862704 hasConceptScore W2240862704C167672396 @default.