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• W2240933503 abstract "ABSTRACT Preexposure prophylaxis (PrEP) using antiretroviral drugs is effective in reducing the risk of human immunodeficiency virus type 1 (HIV-1) infection, but adherence to the PrEP regimen is needed. To improve adherence, a long-acting injectable formulation of the nonnucleoside reverse transcriptase (RT) inhibitor rilpivirine (RPV LA) has been developed. However, there are concerns that PrEP may select for drug-resistant mutations during preexisting or breakthrough infections, which could promote the spread of drug resistance and limit options for antiretroviral therapy. To address this concern, we administered RPV LA to macaques infected with simian immunodeficiency virus containing HIV-1 RT (RT-SHIV). Peak plasma RPV levels were equivalent to those reported in human trials and waned over time after dosing. RPV LA resulted in a 2-log decrease in plasma viremia, and the therapeutic effect was maintained for 15 weeks, until plasma drug concentrations dropped below 25 ng/ml. RT mutations E138G and E138Q were detected in single clones from plasma virus in separate animals only at one time point, and no resistance mutations were detected in viral RNA isolated from tissues. Wild-type and E138Q RT-SHIV displayed similar RPV susceptibilities in vitro , whereas E138G conferred 2-fold resistance to RPV. Overall, selection of RPV-resistant variants was rare in an RT-SHIV macaque model despite prolonged exposure to slowly decreasing RPV concentrations following injection of RPV LA." @default.
• W2240933503 created "2016-06-24" @default.
• W2240933503 creator A5012624975 @default.
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• W2240933503 creator A5038307269 @default.
• W2240933503 creator A5079780905 @default.
• W2240933503 creator A5081126436 @default.
• W2240933503 date "2015-12-01" @default.
• W2240933503 modified "2023-10-17" @default.
• W2240933503 title "Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase" @default.
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• W2240933503 cites W1979285938 @default.
• W2240933503 cites W1981459523 @default.
• W2240933503 cites W1989078988 @default.
• W2240933503 cites W2000761749 @default.
• W2240933503 cites W2001544917 @default.
• W2240933503 cites W2004487100 @default.
• W2240933503 cites W2009419809 @default.
• W2240933503 cites W2012639630 @default.
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• W2240933503 doi "https://doi.org/10.1128/aac.01937-15" @default.
• W2240933503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4649225" @default.
• W2240933503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26438501" @default.
• W2240933503 hasPublicationYear "2015" @default.
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