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- W2241087211 abstract "Stress response and personality play important roles in cravinginduced relapse. Both of these factors are under high genetic influences. Serotonin transporter-linked promoter region (5HTTLPR) is one of the candidate polymorphisms that have been associated with affective disorders and personality. The aim of this study is to investigate the correlations among alcohol craving, personality traits and salivary cortisol level, and the association between 5HTTLPR and these factors. Eighty-seven alcohol-dependent subjects were recruited during a 5-day detoxification treatment. Neuroticism, extraversion and conscientiousness were measured by NEO PI-R. Global alcohol craving level of the week prior to admission was measured by Obsessive Compulsive Drinking Scale; while state alcohol craving level was measured by Alcohol Urge Questionnaire in a morning of day 3–day 5, and a saliva sample was collected subsequently for cortisol measurement. We observed thatglobal alcohol craving prior to treatment was correlated with neuroticism (Spearman’s rho = 0.264, p = 0.021); while state alcohol craving during late stage of detoxification treatment was correlated with conscientiousness (Spearman’s rho = -0.227, p = 0.040) and salivary cortisol level (Spearman’s rho = 0.366; p = 0.010). 5HTTLPR short-allele carriers scored significantly higher in conscientiousness than non-allele carriers after controlling for subjects' age (p = 0.031). Although we did not observed significant association between 5HTTLPR alcohol craving, the influence of 5HTTLPR may be imposed indirectly through conscientious personality traits: short allele is associated with higher conscientiousness. © 2010 The Authors. Journal compilation © 2010 International Society for Neurochemistry" @default.
- W2241087211 created "2016-06-24" @default.
- W2241087211 date "2010-09-12" @default.
- W2241087211 modified "2023-09-26" @default.
- W2241087211 title "Wednesday Session - 20 October 2010" @default.
- W2241087211 doi "https://doi.org/10.1111/j.1471-4159.2010.06944.x" @default.
- W2241087211 hasPublicationYear "2010" @default.
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