FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2241235628> ?p ?o ?g. }

• W2241235628 endingPage "356" @default.
• W2241235628 startingPage "356" @default.
• W2241235628 abstract "To investigate the mechanism and significance of NF-kappaB activation regulated by hepatitis B virus X protein (HBx) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).The expression levels of HBx, p65, IkappaB-alpha and ubiquitin were detected by immunohistochemistry in HCC tissue microarrays (TMA) respectively, and IkappaB-alpha was detected by Western blot in HCC and corresponding liver tissues.The percentage of informative TMA samples was 98.8% in 186 cases with a total of 367 samples. Compared with corresponding liver tissues (60.0%), the HBx expression was obviously decreased in HBV-associated HCC (47.9%, u=2.24, P<0.05). On the contrary, the expressions of p65 (20.6% vs 45.3%, u=4.85, P<0.01) and ubiquitin (8.9% vs 59.0%, u=9.68, P<0.01) were notably elevated in HCC. In addition, IkappaB-alpha had a tendency to go up. Importantly, positive relativity was observed between HBx and p65 (chi2=10.26, P<0.01), p65 and IkappaB-alpha (chi (2)=16.86, P<0.01), IkappaB-alpha and ubiquitin (chi2=8.90, P<0.01) in HCC, respectively.Both active and non-active forms of NF-kappaB are increased in HBV-associated HCC. Variant HBx is the major cause of the enhancement of NF-kappaB activity. The activation always proceeds in nucleus and the proteasome complexes play an important role in the activation." @default.
• W2241235628 created "2016-06-24" @default.
• W2241235628 creator A5003728523 @default.
• W2241235628 creator A5029667848 @default.
• W2241235628 creator A5052803150 @default.
• W2241235628 creator A5078612448 @default.
• W2241235628 creator A5085142676 @default.
• W2241235628 date "2004-01-01" @default.
• W2241235628 modified "2023-10-09" @default.
• W2241235628 title "Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma" @default.
• W2241235628 cites W1543153788 @default.
• W2241235628 cites W1591152328 @default.
• W2241235628 cites W1911781926 @default.
• W2241235628 cites W1969087969 @default.
• W2241235628 cites W1985749562 @default.
• W2241235628 cites W2000506984 @default.
• W2241235628 cites W2008427962 @default.
• W2241235628 cites W2029999536 @default.
• W2241235628 cites W2032531389 @default.
• W2241235628 cites W2035860876 @default.
• W2241235628 cites W2040470926 @default.
• W2241235628 cites W2054321620 @default.
• W2241235628 cites W2058145374 @default.
• W2241235628 cites W2058714321 @default.
• W2241235628 cites W2065851935 @default.
• W2241235628 cites W2070853191 @default.
• W2241235628 cites W2071475337 @default.
• W2241235628 cites W2079792165 @default.
• W2241235628 cites W2082465255 @default.
• W2241235628 cites W2085449895 @default.
• W2241235628 cites W2087097566 @default.
• W2241235628 cites W2087810003 @default.
• W2241235628 cites W2114865123 @default.
• W2241235628 cites W2133367721 @default.
• W2241235628 cites W2138684882 @default.
• W2241235628 cites W2145184113 @default.
• W2241235628 cites W2166781237 @default.
• W2241235628 cites W2315900111 @default.
• W2241235628 cites W2327527491 @default.
• W2241235628 cites W2333852662 @default.
• W2241235628 cites W233697497 @default.
• W2241235628 cites W2490211911 @default.
• W2241235628 cites W2999065750 @default.
• W2241235628 cites W4246637000 @default.
• W2241235628 cites W4379365691 @default.
• W2241235628 doi "https://doi.org/10.3748/wjg.v10.i3.356" @default.
• W2241235628 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4724905" @default.
• W2241235628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14760757" @default.
• W2241235628 hasPublicationYear "2004" @default.
• W2241235628 type Work @default.
• W2241235628 sameAs 2241235628 @default.
• W2241235628 citedByCount "25" @default.
• W2241235628 countsByYear W22412356282012 @default.
• W2241235628 countsByYear W22412356282013 @default.
• W2241235628 countsByYear W22412356282017 @default.
• W2241235628 countsByYear W22412356282019 @default.
• W2241235628 countsByYear W22412356282020 @default.
• W2241235628 crossrefType "journal-article" @default.
• W2241235628 hasAuthorship W2241235628A5003728523 @default.
• W2241235628 hasAuthorship W2241235628A5029667848 @default.
• W2241235628 hasAuthorship W2241235628A5052803150 @default.
• W2241235628 hasAuthorship W2241235628A5078612448 @default.
• W2241235628 hasAuthorship W2241235628A5085142676 @default.
• W2241235628 hasBestOaLocation W22412356281 @default.
• W2241235628 hasConcept C104317684 @default.
• W2241235628 hasConcept C142724271 @default.
• W2241235628 hasConcept C153911025 @default.
• W2241235628 hasConcept C159047783 @default.
• W2241235628 hasConcept C159110408 @default.
• W2241235628 hasConcept C185592680 @default.
• W2241235628 hasConcept C193270364 @default.
• W2241235628 hasConcept C204232928 @default.
• W2241235628 hasConcept C2522874641 @default.
• W2241235628 hasConcept C25602115 @default.
• W2241235628 hasConcept C2775944032 @default.
• W2241235628 hasConcept C2776415932 @default.
• W2241235628 hasConcept C2778019345 @default.
• W2241235628 hasConcept C2780593183 @default.
• W2241235628 hasConcept C49453240 @default.
• W2241235628 hasConcept C502942594 @default.
• W2241235628 hasConcept C55493867 @default.
• W2241235628 hasConcept C64943373 @default.
• W2241235628 hasConcept C67567795 @default.
• W2241235628 hasConcept C71924100 @default.
• W2241235628 hasConcept C86803240 @default.
• W2241235628 hasConceptScore W2241235628C104317684 @default.
• W2241235628 hasConceptScore W2241235628C142724271 @default.
• W2241235628 hasConceptScore W2241235628C153911025 @default.
• W2241235628 hasConceptScore W2241235628C159047783 @default.
• W2241235628 hasConceptScore W2241235628C159110408 @default.
• W2241235628 hasConceptScore W2241235628C185592680 @default.
• W2241235628 hasConceptScore W2241235628C193270364 @default.
• W2241235628 hasConceptScore W2241235628C204232928 @default.
• W2241235628 hasConceptScore W2241235628C2522874641 @default.
• W2241235628 hasConceptScore W2241235628C25602115 @default.
• W2241235628 hasConceptScore W2241235628C2775944032 @default.
• W2241235628 hasConceptScore W2241235628C2776415932 @default.
• W2241235628 hasConceptScore W2241235628C2778019345 @default.

• next