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- W2241236365 abstract "In recent years there has been a growing interest in the model-based control of fermentation processes. In parallel with expensive and time consuming experiments on real life (pilot) plants, simulation studies are very helpful in the stages of modelling the process and designing an efficient controller for it. In this contribution we illustrate this approach in designing an optimal substrate controller for the penicillin G fed-batch fermentation process. Penicillin G is a common antibiotic produced on a large scale. A fed-batch process design in which the rate limiting substrate (glucose) is fed continuously during at least part of the total process time seems to be the preferred fermentation technology. The optimization of product formation during fermentation as part of total process control has gained renewed attention." @default.
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- W2241236365 date "1993-01-01" @default.
- W2241236365 modified "2023-09-26" @default.
- W2241236365 title "Optimal substrate controller design for the penicillin G fed-batch fermentation process using simulations" @default.
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