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- W2241443741 abstract "Abstract IL-6 is an important inflammatory cytokine required for Th17 cell differentiation. IL-17, a proinflammatory cytokine involved in many inflammatory diseases, is produced by Th17 cells, under the control of transforming growth factor-b and IL-6. IL17 may mediate neutrophil recruitment and granulopoiesis through G-CSF-dependent and -independent mechanisms. Using a novel in vitro culture and differentiation system and an in vivo lung inflammation/injury model, we demonstrate that addition of G-CSF and IL17 promotes functional neutrophil generation. The numbers of neutrophils released upon IL-17 stimulation is comparable to or more than that of G-CSF stimulation. In confirmation of the result published by Kolls et al, IL17 induces modest G-CSF production. However, IL-17 also induces a dramatic increase in IL6 expression that is not observed in G-CSF-treated cultures. Furthermore, both G-CSF and IL17-induced granulopoiesis is attenuated in IL6-deficient mice. Our data also show an increased population of lin-/c-kit+/Sca1- cells in IL17 and IL6-treated cultures. The Stat3 and pAKT are activated upon IL17 stimulation and contribute to activation of IL6 transcription. Taken together, IL-17 produced by T cells stimulates granulopoiesis through the release IL-6 and G-CSF and is critical for the initiation of innate immunity." @default.
- W2241443741 created "2016-06-24" @default.
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- W2241443741 date "2009-04-01" @default.
- W2241443741 modified "2023-10-16" @default.
- W2241443741 title "IL17 stimulates granulopoiesis via IL6 induction (93.5)" @default.
- W2241443741 doi "https://doi.org/10.4049/jimmunol.182.supp.93.5" @default.
- W2241443741 hasPublicationYear "2009" @default.
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