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- W2241482697 abstract "As an important steroid, vitamin D is synthesized mainly from 7-dehydrocholesterol in the skin. When it is carried to the liver and kidney sequentially, it is transformed to 1,25-dihydroxyvitamin D3[1,25-(OH)2D3], which is the most active form of vitamin D. Kidney transplant recipients usually have low vitamin D levels, especially in the early post-transplantation period, possibly due to decreased sunlight exposure and intake of immunosuppressant. Traditionally, the recipients will receive vitamin D supplements to treat the osteoporosis or to maintain calcium and phosphorus homeostasis for a long time in the post-transplantation period. Along with the progress in the study of vitamin D receptors (VDR), extraskeletal effects of vitamin D have received more and more attention. VDR exists in many types of cells including activated T cells and tissues, and it is considered as a base of above-mentioned physiological effect of vitamin D. It also possesses potential effects in immune-modulation and anti-infection as well as regulation of bone metabolism. This paper reviews the recent research progress focusing on the effects of vitamin D in immunomodulatory and non-immunomodulatory aspects in order to provide reference for rational administration of vitamin D.DOI: 10.11855/j.issn.0577-7402.2014.03.17" @default.
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- W2241482697 date "2014-03-01" @default.
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- W2241482697 title "Recent progress in clinical application of vitamin D in renal transplantation" @default.
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