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• W2242021504 abstract "UNIVERSITY OF JYVASKYLA Department of Psychology YLIKULJU, TEEMU: An attempt to enhance neurogenesis of mdx mice via aerobic exercise and myostatin inhibition. Master's thesis, 27 p., 1 appendix Supervisor: Miriam Nokia Psychology September 2013 Duchenne`s muscular dystrophy (DMD) is an inherited disorder that occurs with 1 out of every 3600 male infants. It involves muscular weakness, dystrophy and cognitive dysfunction. The disorder is caused by a defective gene for dystrophin protein. It has been hypothesized that cognitive deficit occurs because DMD downregulates patients neurogenesis. Neurogenesis is a process where new brain cells are continuously generated at subventicular zone and dentate gyrus of hippocampus. Cures for DMD are mainly researched with mdx mice. Etiology of the mdx is close enough to that of patients with DMD. This research focuses on an attempt to enhance the neurogenesis of mdx mice via aerobic exercise and myostatin inhibition. Myostatin inhibition enhances mammals’ muscle growth. Research has three main focus: 1. Does aerobic exercise enhance neurogenesis in mdx mice? 2. Do bigger muscles enhance neurogenesis in mdx mice? 3. Does aerobic exercise with bigger muscles enhance neurogenesis in mdx mice? Also the effect of myostatin blocking on running readiness was examined. Myostatin inhibition affected running by decreasing running distances compared to pbs treated runners at the beginning of the experience. Against expectations there where no significant differences in proliferating new born cell count between any of the groups. It seems to be that neither exercise nor bigger muscles or their combination are factors that are sufficient or efficient enough to affect the neurogenesis of mdx mice. The other reasons for not finding any differences between cell counts could be that the neurogenesis of the mdx mice was not affected by the disease." @default.
• W2242021504 created "2016-06-24" @default.
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• W2242021504 date "2013-01-01" @default.
• W2242021504 modified "2023-09-26" @default.
• W2242021504 title "An attempt to enhance neurogenesis of mdx mice via aerobic exercise and myostatin inhibition" @default.
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