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- W2242296970 abstract "Emerging diseases such as influenza have the potential to cause global pandemics; a key intervention will be vaccination. In fact, most infectious diseases remained as major health risks, due to the lack of vaccine or the lack of facilities to deliver the vaccines. Plasmid DNA (pDNA) vaccines provide an antigen-specific protective immunity by expressing a foreign protein within the host cells. This is mimicking intracellular pathogenic infection, and can induce both humoral and cellular immune responses. Thus, non-viral systems, particularly a synthetic pDNA delivery system, are highly desirable in both research and clinical applications. Nasal delivery of vaccines has been an area of interest for the pharmaceutical industries in recent years to overcome the alarming pattern of unsafe injection practices and the poor availability of orally administrated and injectable vaccines. DNA prime-protein boost vaccination involves a heterologous immunisation strategy. This strategy aims to augment immune responses to pathogens. In this study, a microencapsulation method using ultrasonic atomisation has been developed to synthesise biodegradable polymer microspheres (10-20 m) that encapsulated both the pDNA and the mesoporous silica spheres adsorbed with protein. These composite microspheres aimed to achieve a controlled delivery profile of the prime-boost vaccines in the nasal cavity. Vaccines can be released from such polymer microspheres in a sustained and controlled fashion, while non-release biopharmaceuticals are protected from rapid in vivo degradation. This effective method, which can embed biopharmaceutical compounds into biodegradable polymer while protect them from degradation during myriad of processing stages, will find application in large scale production of vaccine delivery system to combat a host of current and emerging infectious diseases." @default.
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- W2242296970 date "2008-01-01" @default.
- W2242296970 modified "2023-09-23" @default.
- W2242296970 title "Inorganic-organic Composite Microspheres for Prime-boost Genetic Therapies via Nasal Cavity" @default.
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