Matches in SemOpenAlex for { <https://semopenalex.org/work/W2242634443> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2242634443 endingPage "783" @default.
- W2242634443 startingPage "783" @default.
- W2242634443 abstract "783 Background: In a previous clinical study (ASCO 2000 # 417), we demonstrated a therapeutic synergism of combined P and V two microtubule poisons with opposite mechanism of action. To optimize efficacy and safety we evaluated a weekly P and biweekly V schedule. Methods: Patients with MBC previously treated with anthracyclines received biweekly V 25 mg/m2 and weekly P 80 mg/m2, 8 weeks course, 2 weeks rest. Results: 20 patients (pts) entered the study, with the following characteristics: median age 64 (range 31–74); performance status 0 (12 pts 60%) and 1 (8 pts 40%); postmenopausal 15 (75%); oestrogen receptor negative 14 (70%); pts relapsing within 12 months after anthracyclin-based adjuvant therapy 5 (25%); 13 pts (65%) received one prior chemotherapy for MBC. A total of 189 weeks of treatment could be achieved, with an average of 9.5 weeks (range 1–16). No toxic death was observed. The most frequent adverse event was grade 2 (1 pt 5%), grade 3 (10 pts 50%) and grade 4 (4 pts 20%) neutropenia, including 5 (25%) febrile neutropenia. Haematological support with G-CSF concerned 12 pts (60%). One grade 4 thrombocytopenia was observed. Non haematological toxicity was uncommon: 4 pts (20%) and 1 pt (5%) experienced grade 1–2 and grade 3 peripheral neurotoxicity respectively; 1 pt (5%) experienced grade 4 nausea-vomiting. An objective response was observed in 10/18 evaluable pts (55.5%; 95% confidence interval=32–78) with 1 complete response and a stable disease was observed in 7/18 pts. The median progression-free survival was 174 days (range 12–440). Conclusions: With haematological support, this regimen is feasible in pts with anthracyclin-resistant MBC. Peripheral neurotoxicity is infrequent and manageable. Clinical benefit is promising. No significant financial relationships to disclose." @default.
- W2242634443 created "2016-06-24" @default.
- W2242634443 creator A5001479918 @default.
- W2242634443 creator A5002036029 @default.
- W2242634443 creator A5018291863 @default.
- W2242634443 creator A5038119847 @default.
- W2242634443 creator A5039049190 @default.
- W2242634443 creator A5044328939 @default.
- W2242634443 creator A5048189258 @default.
- W2242634443 creator A5052852740 @default.
- W2242634443 creator A5065373099 @default.
- W2242634443 creator A5077775252 @default.
- W2242634443 date "2004-07-15" @default.
- W2242634443 modified "2023-10-17" @default.
- W2242634443 title "Weekly paclitaxel (P) combined with biweekly vinorelbine (V) in metastatic breast cancer (MBC): Final results of a clinical phase II study" @default.
- W2242634443 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.783" @default.
- W2242634443 hasPublicationYear "2004" @default.
- W2242634443 type Work @default.
- W2242634443 sameAs 2242634443 @default.
- W2242634443 citedByCount "2" @default.
- W2242634443 crossrefType "journal-article" @default.
- W2242634443 hasAuthorship W2242634443A5001479918 @default.
- W2242634443 hasAuthorship W2242634443A5002036029 @default.
- W2242634443 hasAuthorship W2242634443A5018291863 @default.
- W2242634443 hasAuthorship W2242634443A5038119847 @default.
- W2242634443 hasAuthorship W2242634443A5039049190 @default.
- W2242634443 hasAuthorship W2242634443A5044328939 @default.
- W2242634443 hasAuthorship W2242634443A5048189258 @default.
- W2242634443 hasAuthorship W2242634443A5052852740 @default.
- W2242634443 hasAuthorship W2242634443A5065373099 @default.
- W2242634443 hasAuthorship W2242634443A5077775252 @default.
- W2242634443 hasConcept C121608353 @default.
- W2242634443 hasConcept C126322002 @default.
- W2242634443 hasConcept C141071460 @default.
- W2242634443 hasConcept C197934379 @default.
- W2242634443 hasConcept C2775930923 @default.
- W2242634443 hasConcept C2776694085 @default.
- W2242634443 hasConcept C2777063308 @default.
- W2242634443 hasConcept C2778239845 @default.
- W2242634443 hasConcept C2778850193 @default.
- W2242634443 hasConcept C2780350996 @default.
- W2242634443 hasConcept C2780580376 @default.
- W2242634443 hasConcept C2780852908 @default.
- W2242634443 hasConcept C31760486 @default.
- W2242634443 hasConcept C530470458 @default.
- W2242634443 hasConcept C71924100 @default.
- W2242634443 hasConcept C90924648 @default.
- W2242634443 hasConceptScore W2242634443C121608353 @default.
- W2242634443 hasConceptScore W2242634443C126322002 @default.
- W2242634443 hasConceptScore W2242634443C141071460 @default.
- W2242634443 hasConceptScore W2242634443C197934379 @default.
- W2242634443 hasConceptScore W2242634443C2775930923 @default.
- W2242634443 hasConceptScore W2242634443C2776694085 @default.
- W2242634443 hasConceptScore W2242634443C2777063308 @default.
- W2242634443 hasConceptScore W2242634443C2778239845 @default.
- W2242634443 hasConceptScore W2242634443C2778850193 @default.
- W2242634443 hasConceptScore W2242634443C2780350996 @default.
- W2242634443 hasConceptScore W2242634443C2780580376 @default.
- W2242634443 hasConceptScore W2242634443C2780852908 @default.
- W2242634443 hasConceptScore W2242634443C31760486 @default.
- W2242634443 hasConceptScore W2242634443C530470458 @default.
- W2242634443 hasConceptScore W2242634443C71924100 @default.
- W2242634443 hasConceptScore W2242634443C90924648 @default.
- W2242634443 hasIssue "14_suppl" @default.
- W2242634443 hasLocation W22426344431 @default.
- W2242634443 hasOpenAccess W2242634443 @default.
- W2242634443 hasPrimaryLocation W22426344431 @default.
- W2242634443 hasRelatedWork W1905409013 @default.
- W2242634443 hasRelatedWork W1964431856 @default.
- W2242634443 hasRelatedWork W2006876985 @default.
- W2242634443 hasRelatedWork W2009402447 @default.
- W2242634443 hasRelatedWork W2011790448 @default.
- W2242634443 hasRelatedWork W2045545515 @default.
- W2242634443 hasRelatedWork W2047203002 @default.
- W2242634443 hasRelatedWork W2076675372 @default.
- W2242634443 hasRelatedWork W2087071661 @default.
- W2242634443 hasRelatedWork W2163467469 @default.
- W2242634443 hasVolume "22" @default.
- W2242634443 isParatext "false" @default.
- W2242634443 isRetracted "false" @default.
- W2242634443 magId "2242634443" @default.
- W2242634443 workType "article" @default.