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• W2242644080 abstract "18139 Background: To study whether changes in Fluorodeoxyglucose (FDG)-avid tumor volumes (V PET ) correlate with changes in CT gross tumor volumes (CTGTV) during the course of radiation therapy (RT). Methods: Patients with stage I-III non- small cell lung cancer (NSCLC) were prospectively enrolled in this pilot study and were treated with fractionated RT based therapy with or without chemotherapy. FDG-PET/CT scans were acquired within 2 weeks prior to RT (pre-RT), after 45 Gy of irradiation (during-RT), and 3 months after completion of RT (post-RT). The scans were co-registered within our treatment planning system using the CT portion of each scan. Fused CTGTVs were delineated for each CT dataset. Fused V PET s were auto-contoured using 20%, 30%, 40% and 50% of maximum FDG activities within the tumors as threshold (V PET20 , V PET30 , V PET40 , and V PET50 , respectively) for each PET dataset. Paired T test and linear correlation were used for statistic analysis with all P values obtained using a 2-tailed test. Results are reported as Mean ± StDev. Results: Fifteen patients were enrolled in this pilot study. Pre-RT CTGTVs averaged 130.3 ± 194.7 cm 3 and reduced to 91.7 ± 155.3 cm 3 3 months after RT (P = 0.027). A mean PET threshold of 20.0 ± 10.6% matched best with the CTGTVs pre-RT. For the during-RT PET scans, the best-matched threshold increased to 30.0 ± 10.2% (P < 0.001). No significant correlation was found between changes of V PET and reduction of CTGTV during-RT. During-RT changes of higher FDG-avid V PET significantly correlated with the reduction of CTGTV Post-RT (P values were 0.735, 0.189, 0.022, and 0.029 for V PET20 , V PET30 , V PET40 , and V PET50 , respectively), but during-RT changes of CTGTV did not (P = 0.113). Conclusions: Changes of high FDG-avid tumor volumes during-RT differ in magnitude from CTGTV changes. High FDG-avid tumor volume changes (instead of CTGTV changes) during-RT are correlated with CTGTV changes Post-RT. Further study in a large number of patients is needed to verify these findings. No significant financial relationships to disclose." @default.
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• W2242644080 date "2007-06-20" @default.
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• W2242644080 title "Changes in high FDG-avid tumor volumes during radiation therapy differ from that of CT gross tumor volumes in patients with non-small cell lung cancer" @default.
• W2242644080 doi "https://doi.org/10.1200/jco.2007.25.18_suppl.18139" @default.
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