Matches in SemOpenAlex for { <https://semopenalex.org/work/W2242661323> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2242661323 endingPage "77" @default.
- W2242661323 startingPage "367" @default.
- W2242661323 abstract "Our knowledge about migraine pathogenesis has increased exponentially over the last decade and this greatly due to the advances in genetics. In familial hemiplegic migraine (FHM), the findings of mutations in the CACNA1A gene (19p13), coding for the pore-forming subunit (alpha1A) of neuronal voltage-dependent P/Q-type calcium channels (FHM1), and in the ATP1A2 gene (1q21-23), encoding the alpha2-subunit of the Na+, K+ ATPase ionic pump (FHM2) have focused attention on central nervous system ionic channels and helped to better understand FHM pathophysiology. A dysfunction of these channels modifies neuronal excitability (favouring spreading depression), chemical neurotransmission and, indirectly, neuronal metabolism. These channels may represent targets for novel anti-migraine drugs, which underscores their importance for the frequent forms of migraine (without or with aura). Studies of gene associations, neuromuscular transmission, cerebellar functions, neuronal excitability and metabolism and certain drug effects suggest indeed that ionic channels play a pathogenic role in migraine with aura patients. However, in the majority of patients they are probably not the sole culprit, since most of the frequent forms of migraine seem to have a more complex genetic predisposition based on a number of single nucleotide polymorphisms. The challenge for the next decade is to establish correlations between the geno- and the phenotype of migraine patients which needs more frequent and focused genetic studies and a more precise phenotype, based on clinical as well as on neurophysiologic and metabolic data." @default.
- W2242661323 created "2016-06-24" @default.
- W2242661323 creator A5018653939 @default.
- W2242661323 creator A5019704847 @default.
- W2242661323 date "2004-06-01" @default.
- W2242661323 modified "2023-09-23" @default.
- W2242661323 title "[Genetics of migraines: from ionic channels to single nucleotide polymorphisms?]." @default.
- W2242661323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15346975" @default.
- W2242661323 hasPublicationYear "2004" @default.
- W2242661323 type Work @default.
- W2242661323 sameAs 2242661323 @default.
- W2242661323 citedByCount "1" @default.
- W2242661323 crossrefType "journal-article" @default.
- W2242661323 hasAuthorship W2242661323A5018653939 @default.
- W2242661323 hasAuthorship W2242661323A5019704847 @default.
- W2242661323 hasConcept C104317684 @default.
- W2242661323 hasConcept C122356138 @default.
- W2242661323 hasConcept C126322002 @default.
- W2242661323 hasConcept C135763542 @default.
- W2242661323 hasConcept C153209595 @default.
- W2242661323 hasConcept C169760540 @default.
- W2242661323 hasConcept C170493617 @default.
- W2242661323 hasConcept C200170125 @default.
- W2242661323 hasConcept C2776497919 @default.
- W2242661323 hasConcept C2777350023 @default.
- W2242661323 hasConcept C2778042195 @default.
- W2242661323 hasConcept C2778541695 @default.
- W2242661323 hasConcept C54355233 @default.
- W2242661323 hasConcept C60644358 @default.
- W2242661323 hasConcept C71924100 @default.
- W2242661323 hasConcept C86803240 @default.
- W2242661323 hasConceptScore W2242661323C104317684 @default.
- W2242661323 hasConceptScore W2242661323C122356138 @default.
- W2242661323 hasConceptScore W2242661323C126322002 @default.
- W2242661323 hasConceptScore W2242661323C135763542 @default.
- W2242661323 hasConceptScore W2242661323C153209595 @default.
- W2242661323 hasConceptScore W2242661323C169760540 @default.
- W2242661323 hasConceptScore W2242661323C170493617 @default.
- W2242661323 hasConceptScore W2242661323C200170125 @default.
- W2242661323 hasConceptScore W2242661323C2776497919 @default.
- W2242661323 hasConceptScore W2242661323C2777350023 @default.
- W2242661323 hasConceptScore W2242661323C2778042195 @default.
- W2242661323 hasConceptScore W2242661323C2778541695 @default.
- W2242661323 hasConceptScore W2242661323C54355233 @default.
- W2242661323 hasConceptScore W2242661323C60644358 @default.
- W2242661323 hasConceptScore W2242661323C71924100 @default.
- W2242661323 hasConceptScore W2242661323C86803240 @default.
- W2242661323 hasIssue "6" @default.
- W2242661323 hasLocation W22426613231 @default.
- W2242661323 hasOpenAccess W2242661323 @default.
- W2242661323 hasPrimaryLocation W22426613231 @default.
- W2242661323 hasRelatedWork W143800024 @default.
- W2242661323 hasRelatedWork W1996371117 @default.
- W2242661323 hasRelatedWork W2041729785 @default.
- W2242661323 hasRelatedWork W2058610692 @default.
- W2242661323 hasRelatedWork W2067562508 @default.
- W2242661323 hasRelatedWork W2069107563 @default.
- W2242661323 hasRelatedWork W2075680057 @default.
- W2242661323 hasRelatedWork W2324178486 @default.
- W2242661323 hasRelatedWork W2621019134 @default.
- W2242661323 hasRelatedWork W2739983140 @default.
- W2242661323 hasVolume "59" @default.
- W2242661323 isParatext "false" @default.
- W2242661323 isRetracted "false" @default.
- W2242661323 magId "2242661323" @default.
- W2242661323 workType "article" @default.