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- W2242805464 abstract "OBJECTIVE: To develop a biomarker for Parkinson disease. BACKGROUND: Parkinson disease is a multisystem neurodegenerative disease with deposition of α-synuclein in the central, peripheral and enteric nervous systems. The most prominent manifestations of Parkinson disease are due to central, motor system neurodegeneration but there is also widespread peripheral, autonomic and enteric nervous system degeneration with associated clinical features. DESIGN/METHODS: Twenty patients with Parkinson disease and 14 age and gender matched control subjects underwent examinations, autonomic testing and skin biopsies at the distal leg, distal thigh and proximal thigh. Skin biopsies were stained for PGP9.5, tyrosine hydroxylase, vasoactive intestinal peptide and α-synuclein. The density of intra-epidermal, sudomotor and pilomotor nerve fibers was calculated and the ratio of α-synuclein to nerve innervation (α-synuclein ratio). Results were compared to exam scores and autonomic function testing. RESULTS: Patients with Parkinson disease had a distal sensory and autonomic neuropathy characterized by loss of intra-epidermal and pilomotor fibers (P 0.01). Alpha-synuclein ratios were not increased within sensory nerve fibers. CONCLUSIONS: Alpha-synuclein ratios are elevated within sympathetic adrenergic and sympathetic cholinergic fibers, but not sensory fibers, of patients with Parkinson disease. Higher α-synuclein ratios are associated with greater autonomic dysfunction and more advanced Parkinson disease. These data suggest that the α-synuclein ratio may be a useful biomarker in patients with Parkinson disease. Supported by: NIH NINDS K23NS050209 (CHG) and the RJG Foundation (CHG). Disclosure: Dr. Wang has nothing to disclose. Dr. Freeman has received personal compensation for activities with Pfizer, Abbott, Depomed, Johnson & Johnson, Sanofi, and Chelsea Pharmaceuticals. Dr. Freeman has received personal compensation in an editorical capacity for Autonomic Neuroscience - Basic and Clinical and Clinical Journal of Pain. Dr. Gibbons has nothing to disclose." @default.
- W2242805464 created "2016-06-24" @default.
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- W2242805464 date "2013-02-12" @default.
- W2242805464 modified "2023-09-26" @default.
- W2242805464 title "Cutaneous α-Synuclein Is a Biomarker of Parkinson Disease Severity (S37.002)" @default.
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