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- W2242809081 abstract "The KCL026 human embryonic stem cell line was derived from an embryo donated for research that carried a mutation in the SMN1 gene encoding survival of motor neuron 1, telomeric (exons 7 and 8 deletion). Mutations in this gene are associated with spinal muscular atrophy. The ICM was isolated using laser microsurgery and plated on γ-irradiated human foreskin fibroblasts. Both the derivation and cell line propagation were performed in an animal product-free environment. Pluripotent state and differentiation potential were confirmed by in vitro assays." @default.
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- W2242809081 date "2016-03-01" @default.
- W2242809081 modified "2023-10-13" @default.
- W2242809081 title "Generation of KCL026 research grade human embryonic stem cell line carrying a mutation in SMN1 gene" @default.
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- W2242809081 doi "https://doi.org/10.1016/j.scr.2016.01.005" @default.
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