Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243232194> ?p ?o ?g. }
- W2243232194 endingPage "307" @default.
- W2243232194 startingPage "285" @default.
- W2243232194 abstract "To date, more than 400 absorptive and exsorptive membrane transporters have been identified in the human genome, many of which have been characterized and are known to be important from the perspective of pharmaceutical development. Determining the relative importance of these transporters and their influence on drug disposition, therapeutic efficacy and safety, e.g., drug–drug interactions, has been the focus of considerable research, both in academia and the pharmaceutical industry. The interaction of a drug with transporters can potentially lead to alterations in exposure, resulting in toxicity or in certain instances therapeutic failure. For scientists working in the pharmaceutical industry, the importance of understanding drug–transporter interactions is critical as evidenced by the inclusion of drug transporters in recent regulatory guidances. Transporter scientists at Boehringer Ingelheim provide experimental data and an expert interpretation of these data to project teams and work collaboratively with all supporting functions in efforts to determine the potential clinical impact." @default.
- W2243232194 created "2016-06-24" @default.
- W2243232194 creator A5024345070 @default.
- W2243232194 creator A5024576356 @default.
- W2243232194 creator A5026527326 @default.
- W2243232194 creator A5089659933 @default.
- W2243232194 date "2013-01-01" @default.
- W2243232194 modified "2023-09-27" @default.
- W2243232194 title "Industrial Evaluation of Drug Transporters in ADME" @default.
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