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- W2243238966 abstract "目的：探究在中国汉族人群中,含patatin样磷脂酶域3（patain-like phospholipase domaincontaining protein 3,PNPLA3）I148M基因变异与酒精性肝硬化、慢性乙型病毒性肝炎肝硬化及慢性丙型病毒性肝炎肝硬化易感性及肝脏损伤程度、预后是否存在相关性.方法：本研究纳入224例中国汉族酒精性肝硬化、慢性丙型病毒性肝炎肝硬化、慢性乙型病毒性肝炎肝硬化患者,其中,慢性乙型病毒性肝炎肝硬化患者88例,酒精性肝硬化患者83例,慢性丙型病毒性肝炎肝硬化患者53例及200名健康人群作为对照组.采用探针法基因分型检测PNPLA3 rs738409与肝硬化之间的相关性.结果：PNPLA3 I148M rs738409 G等位基因型在酒精性肝硬化（OR=1.902,P〈0.001）及慢性乙型肝炎肝硬化（OR=1.452,P=0.047）与健康对照组中的频率分布存在显著差异;丙型肝炎肝硬化与健康对照组中的等位基因频率分布差异无统计学意义（P=0.056）.并未得出PNPLA3 I148M rs738409 C〉G与肝硬化原发性肝细胞癌相关（P=0.965）.结论：PNPLA3 rs738409 C〉G在中国汉族人群中与酒精性肝硬化及慢性乙型肝炎肝硬化易感性存在相关性。" @default.
- W2243238966 created "2016-06-24" @default.
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- W2243238966 date "2015-01-01" @default.
- W2243238966 modified "2023-09-25" @default.
- W2243238966 title "Association between patain-like phospholipase domain-containing protein 3 rs738409(C>G) single nucleotide polymorphism and etiology of liver cirrhosis in a Chinese Han population" @default.
- W2243238966 doi "https://doi.org/10.11569/wcjd.v23.i23.3691" @default.
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