Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243310216> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2243310216 abstract "e20500 Background: Despite recent therapeutic advances, PNA remains a significant source of morbidity and mortality among CLL pts. We determined population-level estimates for the incidence and outcome of PNA hospitalizations. We further investigated secular trends in care by comparing cohorts before (1994) and after (2004) the widespread use of multiagent chemoimmunotherapy. Methods: Using data from the U.S. Nationwide Inpatient Sample and ICD-9CM diagnosis codes, we identified all non-governmental hospitalizations of CLL pts for a primary dx of PNA in calendar years 1994 and 2004. Admissions were described by pt demographics (age, gender, race) and comorbidity (Charlson index, presence of chronic lung disease). Ten-year prevalence estimates for CLL were obtained from NCI SEER data and used as denominators in incidence calculations. Outcomes studied included need for intubation, in-hospital mortality, and length of stay (LOS). All analyses were sample weighted. Estimates and 95% confidence limits are reported. Results: PNA was the primary dx for 7316 (13.1%) and 7651 (11.2%) CLL pt admissions in 1994 and 2004, respectively. Incidence of PNA admission was similar in 1994 (140/per 1000 pts, 95%CI 130–151) and 2004 (129/per 1000 pts, 95%CI 119–138). CLL pts admitted in 2004 were older (75.7 v. 74.2 years, p<0.001) and more likely to have at least one Charlson comorbidity (67.6% v. 56.2%, p<0.001) or comorbid chronic lung disease (40.6% v. 28.3%, p<0.001) than pts in 1994. Intubation was rare in both cohorts (<1%) and did not significantly differ by year, but in-hospital mortality was significantly higher in 2004 (11.3% v. 8.2%, p=0.005). However, LOS decreased significantly between 1994 and 2004 (9.2 v. 6.4 days, p<0.001). Conclusions: PNA hospitalization rates for CLL pts have not significantly increased over the last decade despite more aggressive therapies, likely secondary to improved supportive care. However, CLL pts hospitalized for PNA are now older, increasingly likely to suffer from chronic medical illness, and significantly more likely to die while in hospital. Therapuetic strategies targeting older pts with significant comorbidities are needed. No significant financial relationships to disclose." @default.
- W2243310216 created "2016-06-24" @default.
- W2243310216 creator A5000921376 @default.
- W2243310216 creator A5009630384 @default.
- W2243310216 creator A5019749214 @default.
- W2243310216 creator A5030359399 @default.
- W2243310216 creator A5091600784 @default.
- W2243310216 date "2009-05-20" @default.
- W2243310216 modified "2023-09-25" @default.
- W2243310216 title "Trends in pneumonia (PNA) hospitalization among patients (pts) with chronic lymphocytic leukemia (CLL)" @default.
- W2243310216 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.e20500" @default.
- W2243310216 hasPublicationYear "2009" @default.
- W2243310216 type Work @default.
- W2243310216 sameAs 2243310216 @default.
- W2243310216 citedByCount "0" @default.
- W2243310216 crossrefType "journal-article" @default.
- W2243310216 hasAuthorship W2243310216A5000921376 @default.
- W2243310216 hasAuthorship W2243310216A5009630384 @default.
- W2243310216 hasAuthorship W2243310216A5019749214 @default.
- W2243310216 hasAuthorship W2243310216A5030359399 @default.
- W2243310216 hasAuthorship W2243310216A5091600784 @default.
- W2243310216 hasConcept C120665830 @default.
- W2243310216 hasConcept C121332964 @default.
- W2243310216 hasConcept C126322002 @default.
- W2243310216 hasConcept C187212893 @default.
- W2243310216 hasConcept C2777938653 @default.
- W2243310216 hasConcept C2778461978 @default.
- W2243310216 hasConcept C2779159551 @default.
- W2243310216 hasConcept C2780790343 @default.
- W2243310216 hasConcept C2908647359 @default.
- W2243310216 hasConcept C44249647 @default.
- W2243310216 hasConcept C45827449 @default.
- W2243310216 hasConcept C61511704 @default.
- W2243310216 hasConcept C71924100 @default.
- W2243310216 hasConcept C99454951 @default.
- W2243310216 hasConceptScore W2243310216C120665830 @default.
- W2243310216 hasConceptScore W2243310216C121332964 @default.
- W2243310216 hasConceptScore W2243310216C126322002 @default.
- W2243310216 hasConceptScore W2243310216C187212893 @default.
- W2243310216 hasConceptScore W2243310216C2777938653 @default.
- W2243310216 hasConceptScore W2243310216C2778461978 @default.
- W2243310216 hasConceptScore W2243310216C2779159551 @default.
- W2243310216 hasConceptScore W2243310216C2780790343 @default.
- W2243310216 hasConceptScore W2243310216C2908647359 @default.
- W2243310216 hasConceptScore W2243310216C44249647 @default.
- W2243310216 hasConceptScore W2243310216C45827449 @default.
- W2243310216 hasConceptScore W2243310216C61511704 @default.
- W2243310216 hasConceptScore W2243310216C71924100 @default.
- W2243310216 hasConceptScore W2243310216C99454951 @default.
- W2243310216 hasLocation W22433102161 @default.
- W2243310216 hasOpenAccess W2243310216 @default.
- W2243310216 hasPrimaryLocation W22433102161 @default.
- W2243310216 hasRelatedWork W1969588132 @default.
- W2243310216 hasRelatedWork W1984626555 @default.
- W2243310216 hasRelatedWork W2065489001 @default.
- W2243310216 hasRelatedWork W2103767240 @default.
- W2243310216 hasRelatedWork W2182081566 @default.
- W2243310216 hasRelatedWork W2419163947 @default.
- W2243310216 hasRelatedWork W2515655827 @default.
- W2243310216 hasRelatedWork W2581748667 @default.
- W2243310216 hasRelatedWork W2591010906 @default.
- W2243310216 hasRelatedWork W2600233649 @default.
- W2243310216 hasRelatedWork W2752854075 @default.
- W2243310216 hasRelatedWork W2755516324 @default.
- W2243310216 hasRelatedWork W2809159118 @default.
- W2243310216 hasRelatedWork W2928993489 @default.
- W2243310216 hasRelatedWork W2980315876 @default.
- W2243310216 hasRelatedWork W3092451531 @default.
- W2243310216 hasRelatedWork W3096109600 @default.
- W2243310216 hasRelatedWork W3096529196 @default.
- W2243310216 hasRelatedWork W3147121903 @default.
- W2243310216 hasRelatedWork W3192341333 @default.
- W2243310216 isParatext "false" @default.
- W2243310216 isRetracted "false" @default.
- W2243310216 magId "2243310216" @default.
- W2243310216 workType "article" @default.