Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243311102> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2243311102 abstract "We studied the behavioral effects of a novel cholecystokinin tetrapeptide (CCK-4) analogue, A71623, with full agonist activity and high affinity and selectivity for the CCK-A receptor subtype relative to the CCK-B receptor. In tests for anorectic activity, A71623 was found to suppress 60-min intakes of a liquid diet in both deprived and sated rats, and the effects were blocked by a selective CCK-A antagonist, A70104. Compared with CCK-8, A71623 was found to have improved potency and duration of action; the most potent route of administration was intraperitoneal. A71623 also suppressed the intake of a liquid diet and a 0.2 M sucrose solution in lean and obese Zucker rats. In daily injection studies, the anorectic activity of CCK-8 diminished rapidly, whereas the suppressant effects of A71623 on food intakes and body weight gains persisted throughout the 11-day treatment period. Finally, A71623 reduced the spontaneous locomotor activity of rats at doses above those required to suppress intakes. These studies are the first to describe the behavioral effects of a potent and highly selective CCK-A receptor agonist." @default.
- W2243311102 created "2016-06-24" @default.
- W2243311102 creator A5003586590 @default.
- W2243311102 creator A5007967790 @default.
- W2243311102 creator A5008860901 @default.
- W2243311102 creator A5020642706 @default.
- W2243311102 creator A5034997728 @default.
- W2243311102 creator A5068179444 @default.
- W2243311102 creator A5081537163 @default.
- W2243311102 creator A5083473051 @default.
- W2243311102 creator A5086075511 @default.
- W2243311102 date "1992-07-01" @default.
- W2243311102 modified "2023-09-26" @default.
- W2243311102 title "Behavioral effects of A71623, a highly selective CCK-A agonist tetrapeptide" @default.
- W2243311102 doi "https://doi.org/10.1152/ajpregu.1992.263.1.r125" @default.
- W2243311102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1636779" @default.
- W2243311102 hasPublicationYear "1992" @default.
- W2243311102 type Work @default.
- W2243311102 sameAs 2243311102 @default.
- W2243311102 citedByCount "16" @default.
- W2243311102 countsByYear W22433111022015 @default.
- W2243311102 countsByYear W22433111022016 @default.
- W2243311102 countsByYear W22433111022021 @default.
- W2243311102 countsByYear W22433111022022 @default.
- W2243311102 crossrefType "journal-article" @default.
- W2243311102 hasAuthorship W2243311102A5003586590 @default.
- W2243311102 hasAuthorship W2243311102A5007967790 @default.
- W2243311102 hasAuthorship W2243311102A5008860901 @default.
- W2243311102 hasAuthorship W2243311102A5020642706 @default.
- W2243311102 hasAuthorship W2243311102A5034997728 @default.
- W2243311102 hasAuthorship W2243311102A5068179444 @default.
- W2243311102 hasAuthorship W2243311102A5081537163 @default.
- W2243311102 hasAuthorship W2243311102A5083473051 @default.
- W2243311102 hasAuthorship W2243311102A5086075511 @default.
- W2243311102 hasConcept C126322002 @default.
- W2243311102 hasConcept C134018914 @default.
- W2243311102 hasConcept C170493617 @default.
- W2243311102 hasConcept C185592680 @default.
- W2243311102 hasConcept C2776079162 @default.
- W2243311102 hasConcept C2776885963 @default.
- W2243311102 hasConcept C2777369949 @default.
- W2243311102 hasConcept C2777593968 @default.
- W2243311102 hasConcept C2778122271 @default.
- W2243311102 hasConcept C2778938600 @default.
- W2243311102 hasConcept C2779281246 @default.
- W2243311102 hasConcept C2779564779 @default.
- W2243311102 hasConcept C3018685816 @default.
- W2243311102 hasConcept C32110497 @default.
- W2243311102 hasConcept C55493867 @default.
- W2243311102 hasConcept C71924100 @default.
- W2243311102 hasConcept C86803240 @default.
- W2243311102 hasConcept C98274493 @default.
- W2243311102 hasConceptScore W2243311102C126322002 @default.
- W2243311102 hasConceptScore W2243311102C134018914 @default.
- W2243311102 hasConceptScore W2243311102C170493617 @default.
- W2243311102 hasConceptScore W2243311102C185592680 @default.
- W2243311102 hasConceptScore W2243311102C2776079162 @default.
- W2243311102 hasConceptScore W2243311102C2776885963 @default.
- W2243311102 hasConceptScore W2243311102C2777369949 @default.
- W2243311102 hasConceptScore W2243311102C2777593968 @default.
- W2243311102 hasConceptScore W2243311102C2778122271 @default.
- W2243311102 hasConceptScore W2243311102C2778938600 @default.
- W2243311102 hasConceptScore W2243311102C2779281246 @default.
- W2243311102 hasConceptScore W2243311102C2779564779 @default.
- W2243311102 hasConceptScore W2243311102C3018685816 @default.
- W2243311102 hasConceptScore W2243311102C32110497 @default.
- W2243311102 hasConceptScore W2243311102C55493867 @default.
- W2243311102 hasConceptScore W2243311102C71924100 @default.
- W2243311102 hasConceptScore W2243311102C86803240 @default.
- W2243311102 hasConceptScore W2243311102C98274493 @default.
- W2243311102 hasLocation W22433111021 @default.
- W2243311102 hasLocation W22433111022 @default.
- W2243311102 hasOpenAccess W2243311102 @default.
- W2243311102 hasPrimaryLocation W22433111021 @default.
- W2243311102 hasRelatedWork W1966022945 @default.
- W2243311102 hasRelatedWork W1982594208 @default.
- W2243311102 hasRelatedWork W2019482019 @default.
- W2243311102 hasRelatedWork W2027797486 @default.
- W2243311102 hasRelatedWork W2042058597 @default.
- W2243311102 hasRelatedWork W2042173428 @default.
- W2243311102 hasRelatedWork W2081465146 @default.
- W2243311102 hasRelatedWork W2089769840 @default.
- W2243311102 hasRelatedWork W2243311102 @default.
- W2243311102 hasRelatedWork W2413658046 @default.
- W2243311102 isParatext "false" @default.
- W2243311102 isRetracted "false" @default.
- W2243311102 magId "2243311102" @default.
- W2243311102 workType "article" @default.