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- W2243321123 abstract "Assays for serum erythropoietin (EPO) have been available for several decades. In general these assays have been either technically difficult, time consuming and/or expensive. Beckman Coulter has recently introduced the Access EPO assay to measure the EPO level in serum on their random access analysers. The technical performance of this assay kit was evaluated for reproducibility, linearity, recovery, sensitivity and stability, using a Unicel DXi 800 analyser. Samples from 43 normal healthy subjects between the ages of 25 and 61 were used to determine a reference range. Using a log transformed parametric method this was determined to be 3.9 - 15.2 mIU/ml. The technical performance of the assay proved to be consistent with the manufacturer's claims. In order to assess the clinical applications of the assay, samples from 30 previously treated patients with myeloproliferative disease attending our Haematology clinic, were analysed for serum EPO. All samples with a decreased serum EPO level were JAK2 V617F mutation positive and all samples with an increased serum EPO level were JAK2 V617F mutation negative. Samples (n=42) from patients with multiple myeloma were also analysed to evaluate the possibility of identifying patients who might respond to recombinant EPO therapy. None of these patients had EPO levels below the reference range and 45% had an EPO level exceeding the upper limit and this incidence rose to 83% amongst those with a low haemoglobin, suggesting an EPO response. The assay can assist the differential diagnosis of polycythaemia and could provide useful information in several other clinical settings." @default.
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- W2243321123 date "2007-11-01" @default.
- W2243321123 modified "2023-09-26" @default.
- W2243321123 title "An Evaluation of the Technical Performance and Clinical Applications of the Beckman Coulter Access Erythropoietin Immunoassay" @default.
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