FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2243321175> ?p ?o ?g. }

• W2243321175 endingPage "15511" @default.
• W2243321175 startingPage "15511" @default.
• W2243321175 abstract "15511 Background: Previous studies suggest that there are differences in survival among Asian and Caucasian patients with gastric cancer. It remains unclear whether disparities of treatment, differences in staging, or individual tumor biology account for this effect. The present study examines differences among ethnicities in time to tumor recurrence (TTR) in patients with resected gastric cancer. Polymorphisms in thrombin-receptor 1 (PAR1), endostatin (ES), and interleukin 8 (IL-8) are important in angiogenesis and have been implicated in gastric cancer recurrence. We tested whether the frequency of these polymorphisms provide a molecular basis for differences in TTR in different ethnic groups. Methods: Between 1992 and 2007, 105 patients (41 females and 64 males with a median age of 57 yrs; range = 26–85) with gastric adenocarcinoma underwent gastrectomy at the University of Southern California. There were 36 Caucasian, 1 African American, 24 Asian, and 44 Hispanic patients. The median follow-up was 2.4 years (range = 0.1–12.3). 47 of 105 patients (45%) developed tumor recurrence with a 5-year probability of 0.38 ± 0.06. We determined allelic frequencies of PAR1, ES, and IL-8 using PCR-RFLP. Results: Time to recurrence was significantly different by ethnic background (p=0.021, log-rank test). The median TTR for Asians was 7.0 yrs, for Hispanics was 3.7 yrs, and for Caucasians was 1.7 yrs. Gastroesophageal (GE) junction tumors had a shorter TTR compared to other tumor locations (2.1 yrs vs. 3.1 yrs, p=0.021). Allelic frequencies in genes for PAR1 and ES were statistically different between Asians, Hispanics, and Caucasians (PAR1 p=0.008; ES p=0.05), but there were no statistical differences for IL-8. Multivariate analyses including sex and age showed that ethnicity remained significant predicting TTR. Conclusion: Our study demonstrates significant differences in time to recurrence after gastrectomy favoring Asians and Hispanics. Genes in PAR1 and endostatin may provide a molecular basis for differences in TTR and may suggest different biologies of cancer between Caucasian, Hispanic, and Asian populations. Further studies are warranted to characterize molecular markers comparing different ethnic groups with resectable gastric cancer. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bristol-Myers Squibb, Genentech™ BioOncology, ImClone Systems Incorporated, Merck, Pfizer Oncology, Response Genetics Genentech™ BioOncology, Merck, Pfizer Oncology, Roche, sanofi-aventis NIH" @default.
• W2243321175 created "2016-06-24" @default.
• W2243321175 creator A5012414960 @default.
• W2243321175 creator A5015892311 @default.
• W2243321175 creator A5018794650 @default.
• W2243321175 creator A5027630636 @default.
• W2243321175 creator A5039271005 @default.
• W2243321175 creator A5045441776 @default.
• W2243321175 creator A5046604149 @default.
• W2243321175 creator A5066969102 @default.
• W2243321175 creator A5086970208 @default.
• W2243321175 creator A5087374543 @default.
• W2243321175 creator A5091816345 @default.
• W2243321175 date "2008-05-20" @default.
• W2243321175 modified "2023-10-17" @default.
• W2243321175 title "Ethnicity is associated with recurrence in patients with resected gastric cancer" @default.
• W2243321175 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.15511" @default.
• W2243321175 hasPublicationYear "2008" @default.
• W2243321175 type Work @default.
• W2243321175 sameAs 2243321175 @default.
• W2243321175 citedByCount "0" @default.
• W2243321175 crossrefType "journal-article" @default.
• W2243321175 hasAuthorship W2243321175A5012414960 @default.
• W2243321175 hasAuthorship W2243321175A5015892311 @default.
• W2243321175 hasAuthorship W2243321175A5018794650 @default.
• W2243321175 hasAuthorship W2243321175A5027630636 @default.
• W2243321175 hasAuthorship W2243321175A5039271005 @default.
• W2243321175 hasAuthorship W2243321175A5045441776 @default.
• W2243321175 hasAuthorship W2243321175A5046604149 @default.
• W2243321175 hasAuthorship W2243321175A5066969102 @default.
• W2243321175 hasAuthorship W2243321175A5086970208 @default.
• W2243321175 hasAuthorship W2243321175A5087374543 @default.
• W2243321175 hasAuthorship W2243321175A5091816345 @default.
• W2243321175 hasConcept C121608353 @default.
• W2243321175 hasConcept C126322002 @default.
• W2243321175 hasConcept C143998085 @default.
• W2243321175 hasConcept C2780394083 @default.
• W2243321175 hasConcept C2780470880 @default.
• W2243321175 hasConcept C2781182431 @default.
• W2243321175 hasConcept C71924100 @default.
• W2243321175 hasConcept C75920679 @default.
• W2243321175 hasConcept C90924648 @default.
• W2243321175 hasConceptScore W2243321175C121608353 @default.
• W2243321175 hasConceptScore W2243321175C126322002 @default.
• W2243321175 hasConceptScore W2243321175C143998085 @default.
• W2243321175 hasConceptScore W2243321175C2780394083 @default.
• W2243321175 hasConceptScore W2243321175C2780470880 @default.
• W2243321175 hasConceptScore W2243321175C2781182431 @default.
• W2243321175 hasConceptScore W2243321175C71924100 @default.
• W2243321175 hasConceptScore W2243321175C75920679 @default.
• W2243321175 hasConceptScore W2243321175C90924648 @default.
• W2243321175 hasIssue "15_suppl" @default.
• W2243321175 hasLocation W22433211751 @default.
• W2243321175 hasOpenAccess W2243321175 @default.
• W2243321175 hasPrimaryLocation W22433211751 @default.
• W2243321175 hasRelatedWork W2002815722 @default.
• W2243321175 hasRelatedWork W2035238600 @default.
• W2243321175 hasRelatedWork W2131798870 @default.
• W2243321175 hasRelatedWork W2350003905 @default.
• W2243321175 hasRelatedWork W2362090996 @default.
• W2243321175 hasRelatedWork W2362580737 @default.
• W2243321175 hasRelatedWork W2366475112 @default.
• W2243321175 hasRelatedWork W2381201307 @default.
• W2243321175 hasRelatedWork W2405060698 @default.
• W2243321175 hasRelatedWork W2415186990 @default.
• W2243321175 hasVolume "26" @default.
• W2243321175 isParatext "false" @default.
• W2243321175 isRetracted "false" @default.
• W2243321175 magId "2243321175" @default.
• W2243321175 workType "article" @default.